Title: Wired to be human: Insights from transcriptome analysis

Speaker: Prof. Ying ZHU 诸颖

Institutes of Brain Science, Fudan University

Time: 14:00-17:00 PM, April 8(Monday)

Venue: Room 300, 320 Yueyang Road

Host: Prof. Guang-Zhong Wang

          CAS-MPG Partner Institute for Computational Biology

Abstract: Although the human brain is about three times as large as those of our closest living relatives, the nonhuman African great apes, increased size and neural cell counts alone fail to explain its characteristic functionalities. The brain has also undergone microstructural, connectional, and molecular changes in the human lineage, changes likely me-diated by divergent spatiotemporal gene expression. Our integrative analysis of tissue and single-cell transcriptomic data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.

诸颖，研究员，复旦大学脑科学研究院

2008毕业于清华大学获得生物学学士学位，2014年毕业于美国耶鲁大学获得神经生物学博士学位。2014至2017年，于美国耶鲁大学生物统计系和神经生物学系进行联合博士后研究工作，2017年至2019年初于美国耶鲁大学担任副研究科学家。于2019年加入复旦大学脑科学研究院。其研究成果发表在 Nature, Science等多家知名期刊上。

研究方向

大脑发育涉及复杂的过程，需要在时序上精确的基因调控。本实验室运用生物信息学的方法，通过整合分析‘omics’数据，研究人脑在发育、进化，以及相关疾病中的分子和细胞机制。