| 论文作者 |
Peng, QQ; Liu, Y; Huels, A; Zhang, CF; Yu, Y; Qiu, WQ; Cai, XY; Zhao, YP; Schikowski, T; Merches, K; Liu, Y; Yang, YJ; Wang, JC; Zhao, Y; Jin, L; Zhang, L; Krutmann, J; Wang, SJ |
| 摘要 |
Solar lentigines (SLs) are a hallmark of human skin aging. They result from chronic exposure to sunlight and other environmental stressors. Recent studies also imply genetic factors, but findings are partially conflicting and lack of replication. Through a multi-trait based analysis strategy, we discovered that ge-netic variants in telomerase reverse transcriptase were significantly associated with non-facial SL in two East Asian (Taizhou longitudinal cohort, n = 2,964 and National Survey of Physical Traits, n = 2,954) and one Caucasian population (SALIA, n = 462), top SNP rs2853672 (P-value for Taizhou longitudinal cohort = 1.32 x 10-28 and P-value for National Survey of Physical Traits = 3.66 x 10-17 and P-value for SALIA = 0.0007 and Pmeta = 4.93 x 10-44). The same variants were nominally associated with facial SL but not with other skin aging or skin pigmentation traits. The SL-enhanced allele/haplotype upregulated the tran-scription of the telomerase reverse transcriptase gene. Of note, well-known telomerase reverse tran-scriptase-related aging markers such as leukocyte telomere length and intrinsic epigenetic age acceleration were not associated with SL. Our results indicate a previously unrecognized role of telo-merase reverse transcriptase in skin aging-related lentigines formation. |
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