| Single-cell and spatially resolved transcriptomics for liver biology |
| 论文作者 |
Lin, P; Yan, X; Jing, SY; Wu, YH; Shan, YR; Guo, WB; Gu, J; Li, Y; Zhang, HB; Li, H |
| 期刊/会议名称 |
HEPATOLOGY |
| 论文年度 |
2023 |
| 论文类别 |
Review; Early Access |
| 摘要 |
Single-cell transcriptomics enables the identification of rare cell types and the inference of state transitions, whereas spatially resolved transcriptomics allows the quantification of cells and genes in the context of tissues. The recent progress in these new technologies is improving our understanding of the cell landscape and its roles in diseases. Here, we review key biological insights into liver homeostasis, development, regeneration, chronic liver disease, and cancer obtained from single-cell and spatially resolved transcriptomics. We highlight recent progress in the liver cell atlas that characterizes the comprehensive cellular composition; diversity and function; the spatial architecture such as liver zonation, cell communication, and proximity; the cell identity conversion and cell-specific alterations that are associated with liver pathology; and new therapeutic targets. We further discuss outstanding challenges, advanced experimental technologies, and computational methods that help to address these challenges. |
| 影响因子 |
13.5 |
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