| p63 in corneal and epidermal differentiation |
| 论文作者 |
Novelli, F; Ganini, C; Melino, G; Nucci, C; Han, YY; Shi, YF; Wang, Y; Candi, E |
| 期刊/会议名称 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| 论文年度 |
2022 |
| 论文类别 |
Review |
| 摘要 |
The transcription factor p63, belonging to the p53 family, is considered the master regulator of epidermal differentiation, skin, and in general of the differentiation of ectodermal tissues. Mutations in TP63 gene cause several rare ectodermal dysplasia disorders that refers to epidermal structural abnormalities and ocular surface disease, such as Ectrodactyly Ectodermal Dysplasia Clefting (EEC) syndrome. In this review, we discuss the key roles of p63 in keratinocytes and corneal epithelial differentiation, highlighting the function of the DNp63a isoform in driving limbal stem cell and epithelial stem cells commitment. We have summarized the specific ocular phenotypes observed in the TP63-mutation derived EEC syndrome, discussing the current and novel therapeutic strategies for the management of the ocular manifestations in EEC syndrome.(c) 2022 Elsevier Inc. All rights reserved. |
| 卷 |
610 |
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