魏刚

魏刚

博士
表观遗传组学研究组组长

邮箱: weigang@sinh.ac.cn

电话: +86-21-54920557

研究组网站: http://www.picb.ac.cn/epigenome

所属部门: 中国科学院计算生物学重点实验室

个人简历

2012-至  今:中国科学院-马普计算生物学伙伴研究所 研究员
2005-2011年:美国国家健康研究院博士后
2000-2005年:北京大学 生命科学学院 博士
1996-2000年:北京大学 生命科学学院 学士

研究方向

发育和疾病的表观遗传调控

研究内容

1. 细胞命运决定过程中的表观遗传调控机制
2. 疾病的表观遗传调控
3. 染色质高级结构的变化规律和调控功能

代表论著(#第一作者,*通讯作者)

1. Wang X, Yan J, Shen B*, Wei G*. Integrated chromatin accessibility and transcriptome landscapes of doxorubicin-resistant breast cancer cells. Front Cell Dev Biol 2021 Jul 30;9:708066

2. Lu B, Liu M, Gu L, Li Y, Shen S, Guo G, Wang F, He X, Zhao Y, Shang X, Wang L, Yang G, Zhu Q, Cao J, Jiang C, Culleton R, Wei G*, Zhang Q*. The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum. mBio 2021 Apr 27;12(2):e00148-21

3. Lai Y, Cao X, Chen J, Wang L, Wei G*, Wang S*. Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection. Sci Adv 2020 Mar 25;6(13):eaaz1659

4. Zhang Z, Gu J, Yin M, Wang D, Ma C, Du J, Lin Z, Hu S, Wang X, Li Y, Tan G*, Luo H*, Wei G*. Establishment and investigation of a multiple gene expression signature to predict long-term survival in pancreatic cancer. Biomed Res Int 2020 Sep 15;2020:1570862

5. Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G*, Wu Y*, Hou Z*. Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis. Cell Death Differ 2019 Mar;26(3):565-579

6. Li QL, Lei PJ, Zhao QY, Li L, Wei G*, Wu M*. Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation. Epigenomics 2017 Aug;9(8):1077-1092

7. Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G*, Hui L*. Distinct gene expression and epigenetic signatures in hepatocyte-like cells produced by different strategies from the same donor. Stem Cell Reports 2017 Dec 12;9(6):1813-1824

8. Han Z, Wei G*. Computational tools for Hi-C data analysis. Quant Biol 2017 Sep;5(3):215-225

9. Ji S, Zhu L, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G*, Hui L*. Baf60B-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening. Cell Res 2017 May;27(5):642-656

10. Lv X, Han Z, Chen H, Yang B, Yang X, Xia Y, Pan C, Fu L, Zhang S, Han H, Wu M, Zhou Z, Zhang L, Li L, Wei G*, Zhao Y*. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Res 2016 May;26(5):529-542

11. Zhao QY, Lei PJ, Zhang X, Zheng JY, Wang HY, Zhao J, Li YM, Ye M, Li L, Wei G*, Wu M*. Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clin Epigenetics 2016 Mar 31;8:34

12. Gu J, Wang D, Zhang J, Zhu Y, Li Y, Chen H, Shi M, Wang X, Shen B, Deng X, Zhan Q, Wei G*, Peng C*. GFRalpha2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer. Cancer Lett 2016 Oct 1;380(2):434-441

13. Chepelev I#, Wei G#, Wangsa D, Tang Q, Zhao K*. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res 2012 Mar;22(3):490-503

14. Wei G#, Abraham BJ#, Yagi R#, Jothi R#, Cui K, Sharma S, Narlikar L, Northrup DL, Tang Q, Paul WE, Zhu J*, Zhao K*. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011 Aug 26;35(2):299-311