高莹

高莹

博士
表观遗传和营养相关慢性病研究组组长

邮箱: yinggao@sinh.ac.cn

电话: +86-21-54920985

所属部门: 中国科学院营养代谢与食品安全重点实验室

个人简历

2017-至   今:中国科学院上海营养与健康研究所,研究员
2012-2016年:中国科学院上海生命科学研究院营养科学研究所,研究员
2007-2012:美国国立卫生研究院癌症研究所,博士后
2001-2007:美国康奈尔大学营养系,博士
2001-2007:美国康奈尔大学统计系,硕士
1998-2001:北京大学营养与食品卫生系,硕士
  

研究方向

营养分子流行病

研究内容

    以人群研究(流行病学)为基础,结合表观遗传学组学和基因组学等研究方法,系统的探索表观遗传和遗传因素,以及它们与营养等环境因素的相互作用,对生命全程的健康的影响。目前我们主要研究脂肪酸摄入和代谢在代谢紊乱、癌症和生长发育中的作用。我们也感兴趣与寻找可以和营养因素共同影响疾病危险性的表观遗传因素。我们也计划通过人群干预研究来进一步评价营养因素的疾病预防和治疗潜力。
1. 脂肪酸与癌症、代谢紊乱和生长发育的关系
2. 遗传和表观遗传在癌症病因学中的意义
3. 人群干预研究
  

代表论著(#第一作者,*通讯作者)

1. Yajie Xu#, Wenjuan Wang#, Qiuyi Zhang#, Mengnan Yang, Lin Zhang, Hua He, Yu Dong, Fengxiu Ouyang, Ying Gao, Jun Zhang, Tao Zheng*, Zhongcheng Luo*. Docosahexaenoic acid supplementation in gestational diabetes mellitus and neonatal metabolic health biomarkers. Front Nutr 2023 Mar 20;10:1089131

2. Qiuyi Zhang, Ying Gao*, Shuchun Lin, Lynn R Goldin, Yonghong Wang, Holly Stevenson, Daniel C Edelman, Keith Killian, Gerald Marti, Paul S Meltzer, Song Xiang, Neil E Caporaso. Genome-wide DNA methylation profiling in chronic lymphocytic leukaemia. Front Genet 2023 Jan 11;13:1056043

3. Jiongxing Fu, Yan Zheng, Ying Gao, Wanghong Xu. Dietary fiber intake and gut microbiota in human health. Microorganisms 2022 Dec 18;10(12):2507

4. Lan Wang, Zheng Yan, Qian Yu Zhao, Na Liu, Dian Zhen Yu, Bing Xuan Jia, Kai Lin Li, Ying Gao, Aibo Wu. A Prospective Study of Total Urinary Deoxynivalenol in Adolescents in Shanghai, China. Chemosphere 2022 Nov;307(Pt 1):135727

5. Keyu Jia, Shuchen Wang, Qi Dai, Yao Feng, Qiuyi Zhang, Qianyu Zhao, Fuxue Chen, Zi Li, Ying Xiao, Yan Zhong,Zhenni Zhu, Hongwei Wang, Junbo Wang, Zhongcheng Luo, Hong Zhou, Ying Gao*. Breast milk Rubidium and other trace elements were associated with neurocognitive development in infants at age of 8 months. J Nutr 2022 Jun 9;152(6):1507-1514

6. Lijiao Xu, Yunan Liu, Qianyu Zhao, Huaidong Du, Ying Gao, Meijuan Bai, Jun Lv, Yu Guo, Liming Li, Liang Sun, Xu Lin, Zhengming Chen, Yan Chen, Geng Zong. Urinary element profiles and associations with cardiometabolic diseases: a cross-sectional study across ten areas in China. Environ Res 2022 Apr 1;205:112535

7. Xiang Li, Chen Lyu, Zhongcheng Luo, Jing Zhao, Zhongli Wang, Chun Yang, Qi Dai, Hui Li, Yunhua Zhou, Zi Li, Fuxue Chen, Ying Gao*. The roles of IGF2 and DNMT methylation and elongase6 related fatty acids in metabolic syndrome. Food Funct 2021 Oct 19;12(20):10253-10262

8. Keyu Jia, Yao Feng, Thomas J Brenna, Zhongcheng Luo, Jing Zhao, Hong Li, Peiqin Li, Qiuyi Zhang, Qianyu Zhao, Qi Dai, Yan Zhong, Tim Lambers, Hong Zhang, Hong Zhou, Ying Gao*. Breast milk EPA associated with infant distractibility when EPA level is low. Nutrition 2021 Jun:86:111143

9. Miaomiao Shen, Nalini Dhingra, Quan Wang, Chen Cheng, Songbiao Zhu, Xiaolin Tian, Jun Yu, Xiaoxin Gong, Xuzhichao Li, Hongwei Zhang, Xin Xu, Liting Zhai, Min Xie, Ying Gao, Haiteng Deng, Yongning He, Hengyao Niu, Xiaolan Zhao, Song Xiang. Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun 2021 Jan 12;12(1):321

10. Peiqin Li, Boer Shan, Keyu Jia, Fan Hu, Ying Xiao, Jusheng Zhen, Yutang Gao, Huaying Wang, Ying Gao*. Plasma Omega-3 Polyunsaturated Fatty Acids and recurrence of endometrial cancer. BMC Cancer 2020 Jun;20(1):576

11. Xiaoyang Wang, Jianbo Tian, Qianyu Zhao, Nan Yang, Pingting Ying, Xiating Peng, Danyi Zou, Ying Zhu, Rong Zhong, Ying Gao, Jiang Chang, Xiaoping Miao. Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma. Arch Toxicol 2020 Jun;94(6):2039-2046

12. Xin Xu, Huigang Shi, Xiaowen Gong, Pu Chen, Ying Gao, Xinzheng Zhang, Song Xiang. Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump. Elife 2020 May 27:9:e53853

13. Shuchun Lin, Yun Liu, Lynn R Goldin, Chen Lyu, Xiangyin Kong, Yan Zhang, Neil E Caporaso, Song Xiang, Ying Gao*. Sex related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ 2019 Jan 7;10(1):2

14. Kangning Chen, Qianyu Zhao, Xiaofan Li, Jing Zhao, Peiqin Li, Shuchun Lin, Hongwei Wang, Jiajie Zang, Ying Xiao, Wanghong Xu, Fuxue Chen, Ying Gao*. Dietary fiber intake and endometrial cancer risk: A systematic review and meta-analysis. Nutrients 2018 Jul 22;10(7):945

15. Jing Zhao, Xiaofan Li, Xiang Li, Qianqian Chu, Yunhua Zhou, Zi Li, Hong Zhang, Thomas J Brenna, Yiqing Song, Ying Gao*. Associations of plasma very-long-chain SFA and the metabolic syndrome in adults. Br J Nutr 2018 Oct;120(8):855-862

16. Peiqin Li, Jing Zhao, Kumar Kothapalli, Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J. Thomas Brenna, Ying Gao*. A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study. Am J Clin Nutr 2018 Jun 1;107(6):867-875

17. Jie Liu, Shengquan Mi, Li Du, Xiang Li, Jing Zhao, Hong Zhang, Wenhua Zhao*, Ying Gao*. The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population. PLoS One 2018 Mar 20;13(3):e0194639

18. Xiaofan Li, Jing Zhao, Peiqin Li, Ying Gao*. Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 2017 Dec 28;10(1):25

19. Li Du, Yulong Wang, Hang Zhang, Hong Zhang, Ying Gao*. Folate intake and the risk of endometrial cancer: A meta-analysis. Oncotarget 2016 Dec 20;7(51):85176-85184

20. Jing Zhao, Lvy Chen, Jian Gao, Li Du, Boer Shan, Hong Zhang, Huaying Wang, Ying Gao*. Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis. Medicine (Baltimore) 2016 Jul;95(27):e4121

21. Jie Liu, Feixiang Yuan, Jian Gao, Boer Shan, Yulan Ren, Huaying Wang, Ying Gao*. Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials. Oncotarget 2016 Apr 5;7(14):17369-17379

22. Sigurdur Y. Kristinsson#, Ying Gao#, Magnus Björkholm, Sigrun Helga Lund, Jan Sjöberg, Neil Caporaso, Lynn R Goldin, Ola Landgren. Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. Int J Hematol 2015 Jun;101(6):563-568 (# equal contribution)

23. Jing Zhao, Jing Wang, Jinfeng Du, Hongli Xu, Wei Zhang, Quanxing Ni, Herbert Yu, Harvey A. Risch, Yutang Gao, Ying Gao*. Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai. PLoS One 2015 Feb 13;10(2):e0118004

24. Wenqing Li, Nan Hu, Paula L Hyland, Ying Gao, Zhaoming Wang, Kai Yu, Hua Su, Chaoyu Wang, Lemin Wang, Stephen J Chanock, Laurie Burdett, Ti Ding, Youlin Qiao, Jinhu Fan, Yuan Wang, Yi Xu, Jianxin Shi, Fangyi Gu, William Wheeler, Xiaoqin Xiong, Carol Giffen, Margaret A Tucker, Sanford M Dawsey, Neal D Freedman, Christian C Abnet, Alisa M Goldstein, Philip R Taylor. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis 2013 Jul;34(7):1536-1542

25. Ying Gao*, Keith Killian, Hong Zhang, Kai Yu, Qizhai Li, Stephanie Weinstein, Jarmo Virtamo, Margaret Tucker, Philip Taylor, Demetrius Albanes, Paul Meltzer, Neil Caporas. Leukocyte DNA methylation and colorectal cancer among male smokers. World J Gastrointest Oncol 2012 Aug 15;4(8):193-201

26. David E Capo-Ramos, Ying Gao, Jay H Lubin, David P Check, Lynn R Goldin, Angela C Pesatori, Dario Consonni, Pier Alberto Bertazzi, Andrew J Saxon, Andrew W Bergen, Neil E Caporaso, Maria Teresa Landi. Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort. Plos One 2012;7(8):e42945

27. Yoon Jung Park, Herry Herman, Ying Gao, Anders M Lindroth, Benjamin Y Hu, Patrick J Murphy, James R Putnam, Paul D Soloway. Sequences sufficient for programming imprinted germ line DNA methylation defined. PLoS One 2012;7(3):e33024

28. Ying Gao*, Hormuzd Katki, Barry Graubard, Michael Pollak, Michael Martin, Yuzhen Tao, Robert E Schoen, Timothy Church, Richard B Hayes, Mark H Greene, Sonja I Berndt. Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma. Int J Cancer 2012 Jul 15;131(2):E105-E113

29. Gao Y*, Baccarelli A, Shu XO, Ji BT, Yu K, Tarantini L, Yang G, Li HL, Hou L, Rothman N, Zheng W, Gao YT, Chow WH. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study. Br J Cancer 2012 Jan 31;106(3):585-591

30. Freddy Sitas, Sam Egger, Margaret I. Urban, Philip R. Taylor, Christian C. Abnet, Paolo Boffetta, Dianne L. O'Connell, David C. Whiteman, Paul Brennan, Reza Malekzadeh, Michael Pawlita, Sanford M. Dawsey, Tim Waterboer, on behalf of the InterSCOPE Collaboration. Penelope M. Webb, Adèle C. Green, Nicholas K. Hayward, David Zaridze, Ivana Holcatova, Dana Mates, Neonila Szeszenia-Dabrowska, Gilles Ferro, Vladimir Janout, Maria Paula Curado, Ana Maria Menezes, Sergio Koifman, Farhad Islami, Dariush Nasrollahzadeh, Nan Hu, Alisa M. Goldstein, Ying Gao, Ti Ding, Farin Kamangar. InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst 2012 Jan 18;104(2):147-158

31. Ying Gao*, Nan Hu, Xiao You Han, Ti Ding, Carol Giffen, Alisa M Goldstein, Philip R Taylor. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiol 2011 Dec;35(6):e91-e99

32. Ying Gao*, Richard B. Hayes, Wenyi Huang, Neil E. Caporaso, Laurie Burdette, Meredith Yeager, Stephen J. Chanock, Sonja I. Berndt DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis 2011 Jun;32(6):882-887

33. Ying Gao, Alisa M. Goldstein, Dario Consonni, Angela C. Pesatori, Sholom Wacholder, Margaret A. Tucker, Neil E. Caporaso, Lynn Goldin, Maria Teresa Landi. Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer. International Journal of Cancer 2009 Jul 1;125(1):146-152

34. Ying Gao*, Sigurdur Y Kristinsson, Lynn R Goldin, Magnus Björkholm, Neil E Caporaso, Ola Landgren. Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association. Gastroenterology 2009 Jan;136(1):91-98