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代谢调控网络研究团队
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章海兵

章海兵

博士
细胞死亡与免疫代谢研究组组长

邮箱: hbzhang@sinh.ac.cn

电话: +86-21-54920988

所属部门: 中国科学院营养代谢与食品安全重点实验室

个人简历

2017-至　 今：中国科学院上海营养与健康研究所 研究员
2013-2016年：中国科学院上海生命科学研究院营养科学研究所 研究员
2012-2013年：费城儿童医院 博士后
2006-2012年：托马斯杰弗逊大学 博士后
2000-2006年：中国科学院上海生命科学研究院健康科学研究所 博士
1993-1997年：山东大学 微生物系

研究方向

细胞死亡与免疫代谢

研究内容

细胞死亡是维持多细胞生命活动的基础，过多或过少的细胞死亡都会引起疾病的发生。细胞死亡主要包括细胞凋亡和细胞坏死，而近年发现的细胞程序性坏死（Necroptosis）是由包含RIP1/RIP3/MLKL的坏死复合物精密调控的一种重要细胞坏死形式，并且显示细胞程序性坏死通过多种途径参与炎症信号的调控。本研究组主要研究方向为细胞不同死亡方式的互作调控机制及其生理病理意义，探索通过调控和干预细胞死亡治疗相关疾病的新途径。

代表论著（#第一作者，*通讯作者）

  1. Wu X, Zhao X, Li F, Wang Y, Ou Y, Zhang H, Li X, Wu X, Wang L, Li M, Zhang Y, Liu J, Xing M, Liu H, Tan Y, Wang Y, Xie Y, Zhang H, Luo Y, Li H, Wang J, Sun L, Li Y, Zhang H*. MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. Cell Mol Immunol 2024 Nov;21(11):1309-1321.
  2. Deng X#, Wang L#, Zhai Y#, Liu Q, Du F, Zhang Y, Zhao W, Wu T, Tao Y, Deng J, Cao Y, Hao P, Ren J, Shen Y, Yu Z, Zheng Y*, Zhang H*, Wang H*. RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death. Cell Mol Immunol 2024 Jan;21(1):80-90.
  3. Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, Rong W, Liu J, Xing M, Zhao X, Liu H, Ge L, Lv A, Wang L, Wang Z*, Li M*, Zhang H*. ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression. Adv Sci (Weinh) 2023 Nov 27:e2303555.
  4. Wang L, Zhang X, Zhang H, Lu K, Li M, Li X, Ou Y, Zhao X, Wu X, Wu X, Liu J, Xing M, Liu H, Zhang Y, Tan Y, Li F, Deng X, Deng J, Zhang X, Li J, Zhao Y, Ding Q, Wang H, Wang X*, Luo Y*, Zhou B*, Zhang H*. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO Rep 2023 Nov 15:e57925.
  5. Xinyu Wang, Qian Wen, Yanjun Wu, Jingwen Kong, Keying Xu, Jiazheng Jiao, Haibing Zhang*, Kai Wang*, Xiao Xu*, Lixing Zhan*. Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. Cell Death Dis 2023 Oct 12;14(10):673.
  6. Du L, Wu Y, Pan Y, Wang L, Zhang H, Li J, Liu Y, Zhang H*, He P*. Lipopolysaccharide and Glycolipoprotein Coordinately Triggered Necroptosis Contributes to the Pathogenesis of Leptospira Infection in Mice. J Infect Dis 2023 Oct 3;228(7):944-956.
  7. Sun M#, Ma X#, Mu W#, Li H, Zhao X, Zhu T, Li J, Yang Y, Zhang H*, Ba Q*, Wang H*. Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist. Cell Death Dis 2023 Aug 24;14(8):555.
  8. Li M, Liu Y, Xu C, Zhao Q, Liu J, Xing M, Li X, Zhang H, Wu X, Wang L, Ou Y, Wu X, Zhao X, Liu H, Qiu L, Li F, Li J, Rong W, Luo Y, Deng J, Wang X, Wang Z, Zhao Y, Lv A, Li Q, Zhang H*. Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development. Cell Death Differ 2022 Oct;29(10):2034-2045.
  9. Li X#, Li F#, Zhang X, Zhang H, Zhao Q, Li M, Wu X, Wang L, Liu J, Wu X, Ou Y, Xing M, Zhang Y, Deng J, Wang X, Luo Y, Li J, Zhao Y, Zhang H*. Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia. Cell Death Differ 2022 Aug;29(8):1500-1512.
  10. Zhang H, Wu X, Li M, Li X, Wang L, Liu J, Ou Y, Wu X, Xing M, Li F, Zhao X, Liu H, Jones C, Deng J, Xie Q, Zhang Y, Luo Y, Zhao Y, Zhang H*. Caspase-8 Blocks Receptor-Interacting Protein Kinase-1 Kinase-Independent Necroptosis during Embryogenesis. Immunohorizons 2022 Jul 20;6(7):465-475.
  11. Rong W#, Liu C#, Li X, Wan N, Wei L, Zhu W, Bai P, Li M, Ou Y, Li F, Wang L, Wu X, Liu J, Xing M, Zhao X, Liu H, Zhang H*, Lyu A*. Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production. Arterioscler Thromb Vasc Biol 2022 May;42(5):613-631.
  12. Zhang Y, Li M, Li X, Zhang H, Wang L, Wu X, Zhang H*, Luo Y*. Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation. Cell Death Dis 2020 Jul 23;11(7):565.
  13. Zhang H#, Wu XX#, Li XM, Li M, Li F, Wang LX, Zhang XX, Zhang Y, Luo Y, Zhang H*. Crucial role of the Receptor-interacting protein homotypic interaction motifs (RHIM) of RIPK3 in RIPK1 dependent cell death and lymphoproliferative disease. Cell Rep 2020 May 19;31(7):107650.
  14. Zhang XX#, Zhang HW#, Xu CX, Li XM, Li M, Wu XX, Pu WJ, Zhou B, Wang HK, Li DL, Ding QR, Ying H, Wang H, Zhang H*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun 2019 Sep 13;10(1):4158.
  15. Zhao Q#, Yu X#, Li M, Liu Y, Han Y, Zhang X, Li XM, Wu X, Qin J, Fang J, Zhang H*. MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses. Cancer Lett 2019 Sep 10;459:100-111.
  16. Zhang X, Zhang H*. Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME. Sci China Life Sci 2018 Jun;61(6):739-740.
  17. Xu C, Wu X, Zhang X, Xie Q, Fan C, Zhang H*. Embryonic lethality and host immunity of RelA-deficient mice is mediated by both apoptosis and necroptosis. J Immunol 2018 Jan 1;200(1):271-285.
  18. Liu Y#, Fan C#, Zhang Y, Yu X, Wu X, Zhang X, Zhao Q, Zhang H, Xie Q, Li M, Li X, Ding Q, Ying H, Li D, Zhang H*. RIP1 Kinase Activity dependent roles in embryonic development of Fadd-deficient mice. Cell Death Differ 2017 Aug;24(8):1459-1469.
  19. Yu X#*, Zhao Q#, Zhang X, Zhang H, Liu Y, Wu X, Li M, Li X, Zhang J, Ruan X, Zhang H*. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation. Oncotarget 2017 Jun 27;8(40):67300-67314.
  20. Zhao Q, Yu X, Zhang H, Liu Y, Zhang X, Wu X, Xie Q, Li M, Ying H, Zhang H*. RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell Rep 2017 Apr 25;19(4):798-808.
  21. Zhang X#, Fan C#, Zhang H, Zhao Q, Liu Y, Xu C, Xie Q, Wu X, Yu X, Zhang J, Zhang H*. MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome. Cell Rep 2016 Sep 20;16(12):3247-3259.
  22. Fan C#, Pu W#, Wu X, Zhang X, He L, Zhou B*, Zhang H*. Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death Dis 2016 Sep 1;7(9):e2351.
  23. Yu X, Zhao Q, Zhang H, Fan C, Zhang X, Xie Q, Xu C, Liu Y, Wu X, Han Q*, Zhang H*. Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages. Acta Biochim Biophys Sin 2016 May;48(5):454-461.
  24. Zhang H, Zhang X, Fan C, Xie Q, Xu C, Zhao Q, Liu Y, Wu X, Zhang H*. A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells. Biochem Biophys Res Commun 2016 Mar 18;471(4):528-532.
  25. Zhang H, Zhou X, McQuade T, Li J, Chan FK*, Zhang J*. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011 Mar 17;471(7338):373-376.
  26. Zhang H#, Hou YJ#, Han SY, Zhang EC, Huebner K, Zhang J*. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Int Immunol 2009 Jun;21(6):691-703.
  27. Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J*. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol 2009 Jan 1;182(1):207-215.
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