邮箱: zhangls@sinh.ac.cn
电话: +86-21-
所属部门: 肿瘤与微环境重点实验室
2026.08－至 今：中国科学院上海营养与健康研究所 研究员
2021.08－2026.07：中国科学院脑科学与智能技术卓越创新中心 博士后
2018.05－2020.04：芝加哥大学生物科学部 博士联合培养
2014.09－2021.06：中国科学院分子细胞科学卓越创新中心 博士
2010.09－2014.06：山东大学生命科学学院 学士
基因体内功能的高通量解析及衰老与衰老相关疾病的干预研究
运用高通量体内扰动测序（Perturb-seq）和单细胞多组学等前沿技术，系统解析基因在生理和病理状态下的体内功能，筛选衰老与衰老相关疾病（如神经退行性疾病、代谢性疾病等）的新型治疗靶点，并在此基础上开发相应的靶向干预策略。研究方向包括：（1）体内Perturb-seq系统的优化和升级；（2）基因在体内生理和病理条件下的功能图谱绘制；（3）衰老与衰老相关疾病新型治疗靶点的高通量筛选及靶向干预策略的开发。
1. Liansheng Zhang#, Qi Ma#, Xiangrui Kong#, Weijuan Zou#, Bo Wang#, Bin Wu#, Shicheng Cai, Tao Bai, Runlin Tan, Ziji Dai, Xingyu Liu, Zhiheng Jia, Meimei Zhang, Tianwen Li, Yuanyi Zheng*, Xinde Hu*, Jianrong Wu*, Zhengzheng Xu*, Haibo Zhou*. Mapping transcription factor functions in astrocytes using in vivo gain-of-function Perturb-seq. Science. 2026;392(6796):eadw2156. doi:10.1126/science.adw2156
2. Liansheng Zhang#,*, Xiangrui Kong#, Qi Ma#, Xinde Hu#,*, Shicheng Cai#, Bo Wang#, Weijuan Zou, Tao Bai, Meimei Zhang, Liu Fan, Runlin Tan, Ziji Dai, Zhiheng Jia, Tianwen Li, Xingyu Liu, Huatai Xu, Jianrong Wu, Yuanyi Zheng, Zhengzheng Xu*, Haibo Zhou*. Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq. Nature Genetics. 2026. doi:10.1038/s41588-026-02638-3
3. Liansheng Zhang#,*, Zhengzheng Xu#, Zhiheng Jia#, Shicheng Cai#, Qiang Wu, Xingyu Liu, Xinde Hu, Tao Bai, Yongyu Chen, Tianwen Li, Zhen Liu, Bin Wu, Jianhong Zhu, Haibo Zhou*. Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration. Nature Aging. 2025;5(3):468-485. doi:10.1038/s43587-024-00792-z.
4. Tianwen Li#, Liansheng Zhang#, Peng Wang#, Jingyu Yu#, Junjie Zhong#, Qisheng Tang, Tongming Zhu, Kezhu Chen, Fengshi Li, Pengjie Hong, Jiachen Wei, Xicai Sun, Guangchao Ji, Bin Song*, Jianhong Zhu*. Extracellular vesicles from neural stem cells safeguard neurons in intracerebral hemorrhage by suppressing reactive astrocyte neurotoxicity. Cell Reports. 2024;43(10):114854. doi:10.1016/j.celrep.2024.114854.
5. Liansheng Zhang#, Zhiheng Jia#, Qiang Wu#, Tao Bai, Bo Wang, Xinde Hu, Tianwen Li, Xingyu Liu, Jiqiang Fu, Yuelei Chen, Xiaoyan Ding, Zhen Liu, Zhengzheng Xu*, Haibo Zhou*. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice. Nature Metabolism. 2023;5(10):1787-1802. doi:10.1038/s42255-023-00887-8.
6. Tianwen Li#, Liansheng Zhang#, Tao Lu#, Tongming Zhu#, Canbin Feng, Ni Gao, Fei Liu, Jingyu Yu, Kezhu Chen, Junjie Zhong, Qisheng Tang, Quan Zhang, Xiangyang Deng, Junwei Ren, Jun Zeng, Haibo Zhou*, Jianhong Zhu*. Engineered extracellular vesicle-delivered CRISPR/CasRx as a novel RNA editing tool. Advanced Science. 2023;10(10):e2206517. doi:10.1002/advs.202206517.
7. Liansheng Zhang#,*, Jie Li#, Anning Lin*. Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice. STAR Protocols. 2021;2(4):100915. doi:10.1016/j.xpro.2021.100915.
8. Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S Sisodia, Yong-Hui Jiang, Xiaohua Cao, Naihe Jing*, Anning Lin*. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience, 2021;24(9):102942. doi:10.1016/j.isci.2021.102942.
9. Jie Li#, Liansheng Zhang#, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang, Anning Lin*. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. eLife. 2020;9:e56309. doi:10.7554/eLife.56309.
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