李飞

李飞

博士
代谢重塑与细胞命运决定研究组组长

邮箱: fei.li@sinh.ac.cn

电话: +86-21-

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历

2025.01-至  今:中国科学院上海营养与健康研究所 研究员
2021.06-2024.12:中国科学院分子细胞科学卓越创新中心 博士后/副研究员
2016.09-2021.06:中国科学院分子细胞科学卓越创新中心 博士
2012.09-2016.06:西北农林科技大学 学士

研究方向

代谢重塑与细胞命运决定

研究内容

聚焦“代谢重塑与肿瘤生物学”的基础和临床科学问题,结合单细胞多组学、类器官培养、高通量筛选和基因编辑谱系示踪小鼠等传统和新兴实验技术手段,从代谢和免疫的整合生物学角度解析肿瘤细胞和肿瘤微环境细胞命运决定的调控机制,开发新型肿瘤防治策略。主要研究方向包括:(1)内源激素代谢平衡与肿瘤免疫调控;(2)外源营养代谢干预与肿瘤精准防治。

代表论著(#第一作者,*通讯作者)

  1. Li F#, Dai PF#, Shi HL#, Zhang YJ#, He J, Gopalan A, Li D, Chen Y, Du YR, Xu GL, Yang WW*, Liang C*, Gao D*. LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer. Cell Research 2025 In press.
  2. Li F#, Xing XD#, Jin QQ#, Wang XM#, Dai PF#, Han M#, Shi HL, Zhang Z, Shao XL, Peng YY, Zhu YQ, Xu JY, Li D, Chen Y, Wu W, Wang Q, Yu C*, Chen L*, Bai F*, Gao D*. Sex differences orchestrated by androgens at single-cell resolution. Nature 2024 May;629(8010):193-200.
  3. Li X#, Li F#, Ye F#, Guo HT, Chen WT, Jin J, Wang YR, Dai PF, Shi HL, Tao HR, Dang WZ, Ding YL, Wang MC, Jiang HL, Chen KX, Zhang NX, Gao D*, Zhang YY*, Luo C*. Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer. Cell Reports 2023 Jul 25;42(7):112798.
  4. Han M#, Li F#*, Zhang YH#, Dai PF, He J, Li YG, Zhu YQ, Zheng JK, Huang H, Bai F, Gao D*. FOXA2 drives lineage plasticity and Kit pathway activation in neuroendocrine prostate cancer. Cancer Cell 2022 Nov 14;40(11):1306-1323.
  5. Peng JY#, Li F#, Wang J, Wang CX, Jiang YA, He J, Yuan K, Bei JX, Wang V, Zhou B, Chen LN, Gao D*, Zhao Y*. Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury. Cell Discovery 2022 Nov 1;8(1):118.
  6. Li F#, Han M#, Dai PF#, Xu W#, He J#, Tao XT#, Wu Y#, Tong XY, Xia XY, Guo WX, Zhou YJ, Li YG, Zhu YQ, Zhang XY, Liu Z, Aji R, Cai X, Li YT, Qu D, Chen Y, Jiang SB, Wang Q, Ji HB, Xie YH*, Sun YH*, Lu L*, Gao D*. Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide. Nature Communications 2021 Feb 8;12(1):866.
  7. Li F#, Yuan QY#, Di W#, Xia XY#, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y*, Chen Y*, Gao D*. ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming. Journal of Clinical Investigation 2020 Nov 2;130(11):5924-5941.
  8. Tang J#, Wang HX#, Huang XZ#, Li F#, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L*, Gao D*, Zhou B*. Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020 Jan 2;26(1):81-96.