荆清

荆清

博士
核酸与分子医学研究组组长

邮箱: qjing@sinh.ac.cn

电话: +86-21-54920609

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历

2017-至   今:中国科学院上海营养与健康研究所 研究员
2005-2016年:中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2000-2004年:美国The Scripps Research Institute 访问学者
1997-1999年:中国科学院上海细胞生物学研究所 博士后
1997-2000年:第二军医大学长海医院心内科,主治医师,讲师
1990-1997年:第二军医大学长海医院心内科,医师,助教
1994-1997年:第二军医大学 临床医学 博士
1984-1990年:第二军医大学 临床医学 学士
  

研究方向

核酸与分子医学

研究内容

  1、人类干细胞向心血管系统重要谱系细胞的定向分化机制及其临床转化应用;
  2、利用若干重要模式生物研究心血管系统发育以及器官组织再生分子的机制、及其在再生医学中应用前景;
  3、非编码RNA介导基因表达调控的分子机制与疾病发病机制、诊断治疗研究。

  

代表论著(#第一作者,*通讯作者)

1. Guo FH#, Guan YN#, Guo JJ, Zhang LJ, Qiu JJ, Ji Y, Chen AF, Jing Q*. Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscler Thromb Vasc Biol 2022 Mar;42(3):326-342

2. Gao LB, Wang YH, Liu ZH, Sun Y, Cai P, Jing Q*. Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence. Aging Cell 2021 Oct;20(10):e13483

3. Guan YN, Li Y, Roosan M, Jing Q*. Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity. Sci China Life Sci 2021 Jul;64(7):1077-1086

4. Li FF, Liang YL, Han XS, Guan YN, Chen J, Wu P, Zhao XX, Jing Q*. ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacol Sin 2021 Mar;42(3):414-421

5. Hu YX, Zhu RF, Qin YW, Zhao XX, Jing Q*. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Atherosclerosis 2020 Sep;309:56-64.

6. Wang C, Yang ZZ, Guo FH, Shi S, Han XS, Zeng A, Lin H, Jing Q*. Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. J Biol Chem 2019 Jun 21;294(25):9873-9887

7. Han XS, Wang C, Guo FH, Huang S, Qin YW, Zhao XX, Jing Q*. Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration. Protein Cell 2019 Jan;10(1):43-59

8. Song XW#, Zou LL#, Cui L, Li SH, Qin YW, Zhao XX, Jing Q*. Plasma miR-451 with echocardiography serves as a diagnostic reference for pulmonary hypertension. Acta Pharmacol Sin 2018 Jul;39(7):1208-1216

9. Wang C, Jing Q*. Non-coding RNAs as biomarkers for acute myocardial infarction. Acta Pharmacol Sin 2018 Jul;39(7):1110-1119

10. Qi MY*#, Song JW#, Zhang Z, Huang S, Jing Q*. P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization. Mol Biol Cell 2018 Apr 15;29(8):988-1002

11. Li Y*, Zeng A, Han XS, Li G, Li YQ, Shen B**, Jing Q*. Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea. Genom Data 2017 Oct 25;14:114-125

12. Dong J#, Bao J#, Feng R#, Zhao Z, Lu Q, Wang G, Li H, Su D, Zhou J*, Jing Q*, Jing Z*. Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection. Sci Rep 2017 Oct 6;7(1):12784

13. Qiu XX, Liu Y, Zhang YF, Guan YN, Jia QQ, Wang C, Liang H, Li YQ, Yang HT, Qin YW, Huang S, Zhao XX, Jing Q*. Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis. J Am Heart Assoc 2017 Oct 2;6(10):e005295

14. Li Y*, Zeng A, Li G, Guan YN, Yang HT, Shen B**, Jing Q*. Dynamic regulation of small RNAome during the early stage of cardiac differentiation from pluripotent embryonic stem cells. Genom Data 2017 May 3;12:136-145

15. Chen J, Zhu RF, Li FF, Liang YL, Wang C, Qin YW, Huang S, Zhao XX*, Jing Q*. MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. Arterioscler Thromb Vasc Biol 2016 Dec;36(12):2381-2393

16. Zeng A, Li YQ, Wang C, Han XS, Li G, Wang JY, Li DS, Qin YW, Shi Y, Brewer G, Jing Q*. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol 2013 Apr 29;201(3):409-425

17. Zou J, Li WQ, Li Q, Li XQ, Zhang JT, Liu GQ, Chen J, Qiu XX, Tian FJ, Wang ZZ, Zhu N, Qin YW, Shen B, Liu TX*, Jing Q*. Two Functional MicroRNA-126s Repress a Novel Target Gene P21-Activated Kinase1 to Regulate Vascular Integrity in Zebrafish. Circ Res 2011 Jan 21;108(2):201-209

18. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW*, Jing Q*. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J 2010 Mar;31(6):659-666