邮箱: xykong@sinh.ac.cn
电话: +86-21-54920606
所属部门: 中国科学院肿瘤与微环境重点实验室
2017-至 今：中国科学院上海营养与健康研究所 研究员
2002-2016年：中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 研究员
1997-2002年：中国科学院上海生物工程研究中心 副研究员、研究员
1995-1997年：德国马普研究所分子遗传学系 访问学者
1988-1995年：中国医学科学院血液学研究所 研究实习员、助理研究员
1983-1988年：山东医科大学大学 医学系 学士
疾病易感基因识别和功能研究
分子遗传学实验室致力于探索人类疾病的遗传基础。通过经典的分子细胞遗传学技术、基因组学、表观遗传学、生物信息学、细胞生物学和模式生物等研究，我们完成了系统的、独创性的研究工作，在疾病基因鉴定和功能研究方面取得了多项显著成果。基于传统的定位候选克隆策略，确定了人类单基因疾病相关的多个基因（Nat Genet, 2001; Nat Genet, 2002; Genomics, 2002; Am J Hum Genet, 2010; J Mol Cell Biol, 2014）。依靠干湿结合的实验建立了识别复杂疾病的基因组变异的核心功能的一种有效的统计分析方法（PLoS Genet, 2011; PLoS One, 2010）。发现了一系列基因表达调节的新规则（Genome Biol, 2008; Genome Biol, 2009; Genome Biol, 2009; Cell Res, 2010; Mol Biol Evol, 2013; Nucleic Acids Res, 2014）。这些研究为进一步阐明疾病相关机制和治疗药物的开发奠定了坚实的基础。发表论文120余篇，获得国际专利授权四项，国家专利授权五项。相关研究成果曾获国家自然科学奖二等奖、国家自然科学奖二等奖、上海市自然科学奖一等奖和二等奖。现致力于整合多组学方法揭示肿瘤发生发展的机制，拟通过多组学数据的整合分析寻找到靶向癌症疗法的新途径，为精准医疗做出贡献。
1. Wang R, Zhang Y, Guo S, Pei S, Guo W, Wu Z, Wang H, Wang M, Li Y, Zhu Y, Meng LH, Lang J, Jin G*, Xiao Y*, Hu L*, Kong X*. Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity. iScience 2023 Jan 13;26(2):105954
2. Guo W#, Zhang Y#, Guo S#, Mei Z, Liao H, Dong H, Wu K, Ye H, Zhang Y, Zhu Y, Lang J, Hu L*, Jin G*, Kong X*. Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer. Commun Biol 2021 Aug 31;4(1):1019
3. Liao H#, Zhang Y, Guo W, Wang X, Wang H, Ye H, Wu K, Zhang YH, Guo L, Zhu Y, Guo Y, Hu L*, Liu G*, Kong X*. Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation. mSystems 2021 Jun 29;6(3):e0004921
4. Huang J, Zhang Y, Ma Q, Zhang Y, Wang M, Zhou Y, Xing Z, Jin M, Hu L, Kong X*. Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression. Front Genet 2020 Jun 24;11:665
5. Ma Q, Wu K, Li H, Li H, Zhu Y, Hu G*, Hu L*, Kong X*. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep 2019 Dec 27;9(1):20021
6. Zhang YH#, Huang T#, Chen L#, Xu Y, Hu Y, Hu LD*, Cai Y*, Kong X*. Identifying and analyzing different cancer subtypes using RNA-seq data of blood platelets. Oncotarget 2017 Sep 15;8(50):87494-87511
7. Zhang YH, Xing Z, Liu C, Wang S, Huang T, Cai YD, Kong X*. Identification of the core regulators of the HLA I-peptide binding process. Sci Rep 2017 Feb 17;7:42768
8. Wang M, Zhang P, Shu Y, Yuan F, Zhang Y, Zhou Y, Jiang M, Zhu Y, Hu L, Kong X*, Zhang Z*. Alternative splicing at GYNNGY 5' splice sites: more noise, less regulation. Nucleic Acids Res 2014 Dec 16;42(22):13969-13980
9. Xie J, Wu X, Ren H, Wang W, Wang Z, Pan X, Hao X, Tong J, Ma J, Ye Z, Meng G, Zhu Y, Kiryluk K, Kong X, Hu L*, Chen N*. COL4A3 mutations cause focal segmental glomerulosclerosis. J Mol Cell Biol 2014 Dec;6(6):498-505
10. Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G, Hurst LD, Zhang J, Hu L, Kong X*. Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep 2014 Aug 12;4:6036
11. Zhang Y, Castillo-Morales A, Jiang M, Zhu Y, Hu L, Urrutia AO, Kong X*, Hurst LD*. Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Mol Biol Evol 2013 Dec;30(12):2588-2601
12. Liu Y, Zhang L, Xu S, Hu L, Hurst LD, Kong X*. Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study. Sci Rep 2013;3:2147
13. Liu Y, Xu H, Chen S, Chen X, Zhang Z, Zhu Z, Qin X, Hu L, Zhu J, Zhao G, Kong X*. Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common diseases. PLoS Genet 2011;7(3):e1001338
14. Zhang Z, Zhou L, Hu L, Zhu Y, Xu H, Liu Y, Chen X, Yi X, Kong X*, Hurst LD*. Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation. Mol Syst Biol 2010 Dec 14;6:442
15. Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X*. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. PLoS One 2010 Aug 20;5(8):e12185
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