邮箱: weijunpan@sinh.ac.cn
电话: +86-21-54923309
所属部门: 中国科学院营养代谢与食品安全重点实验室
2017-至 今：中国科学院上海营养与健康研究所 研究员
2012-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2009-2012年：美国国立卫生研究院 儿童健康与人类发育研究所 博士后
2005-2009年：美国耶鲁大学，医学院药学系 博士后
1999-2005年：中国科学院上海生命科学研究院生化与细胞所 理学博士 导师：李林 研究员
1995-1999年：华东理工大学 生物工程学院 生物化学系 理学学士
造血-循环系统的发育与稳态
主要从事造血-循环系统发育与稳态调控的信号转导机理研究。通过整合遗传筛选、遗传定位和活体成像、单细胞分析、生化分析和小分子化合物大规模筛选等研究手段，探索微环境信号网络调控中胚层组织器官共发育、稳态维持及相关疾病过程的分子机制。近期重点研究：（1）血管与造血干细胞协同发育；（2）血管网络形成及稳态调控；（3）造血干细胞归巢及增殖分化的分子细胞调控基础，聚焦若干跨膜蛋白质分子、酯/脂质分子及膜动态平衡为核心的信号转导机制研究，积极推进相关人类疾病致病机理及临床转化应用研究。
1. Shuang Wu#, Kai Chen#, Tao Xu#, Ke Ma, Lei Gao, Cong Fu, Wenjuan Zhang, Changbin Jing, Chunguang Ren, Min Deng, Yi Chen, Yi Zhou, Weijun Pan*, Xiaoe Jia*. Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Front Cell Dev Biol 2021 Oct 13;9:709923.
2. Xiaofen Liu, Wenjuan Zhang, Changbin Jing, Lei Gao, Cong Fu, Chunguang Ren, Yimei Hao, Mengye Cao, Ke Ma*, Weijun Pan*, Dantong Li*. Mutation of Gemin5 Causes Defective Hematopoietic Stem/Progenitor Cells Proliferation in Zebrafish Embryonic Hematopoiesis. Front Cell Dev Biol 2021 Apr 30;9:670654.
3. Lantian Wang#, Jing Fan#, Lili Han#, Haonan Qi#, Yimin Wang, Hongye Wang, Suli Chen, Lei Du, Sheng Li, Yunbin Zhang, Wei Tang, Gaoxiang Ge, Weijun Pan*, Ping Hu*, Hong Cheng*. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis 2020 May 11;11(5):357.
4. Wencao Zhao#, Le Cao#, Hanru Ying#, Wenjuan Zhang, Dantong Li, Xiaolong Zhu, Wenzhi Xue, Shuang Wu, Mengye Cao, Cong Fu, Haonan Qi, Yimei Hao, Yun-Chi Tang, Jun Qin, Tao P Zhong, Xiaoxi Lin, Luyang Yu, Xuri Li, Lin Li, Dianqing Wu, Weijun Pan*. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res 2019 Nov;29(11):895-910.
5. Dantong Li#, Wenzhi Xue#, Mei Li#, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O. Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu，Weijun Pan*. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature 2018 Dec;564(7734):119-124.
6. Xiaoli He#, Wenjuan Zhang#, Chen Yan#, Fen Nie, Chen Li, Xiaofen Liu, Cong Fei, Shengdi Li, Xiaomin Song, Yingying Jia, Rong Zeng, Dianqing Wu, Weijun Pan*, Xiaojiang Hao*, Lin Li*. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity. Cell Discov 2017 Jan 31;3:1700.
7. Xiao-E Jia#, Tao Xu#, Ke Ma#, Lei Gao, Shuang Wu, Cong Fu, Wenjuan Zhang, Zhizhang Wang, Kaiyu Liu, Mei Dong, Changbin Jing, Chunguang Ren, Zhiwei Dong, Yi Chen, Yi Jin, Qiuhua Huang, Xing Chang, Min Deng, Li Li, Lingfei Luo, Jun Zhu, Yongjun Dang, Hung-Chun Chang, Leonard I. Zon, Yi Zhou*, Saijuan Chen*, Weijun Pan*. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res 2015 Aug;25(8):946-962.
8. Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiaoe Jia, Shuang Wu, XinSun, Mei Dong, Min Deng, Yi Chen, Wenge Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon, Weijun Pan*. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet 2015 Jul 1;11(7):e1005346.
9. Ingyu Kim#, Weijun Pan#*, Sara A. Jones, Youxin Zhang, Xiaowei Zhuang, Dianqing Wu*. Clathrin and AP2 are required for PtdIns(4,5)P-2-mediated formation of LRP6 signalosomes. J Cell Biol 2013 Feb 18;200(4):419-428.
10. Weijun Pan#, Van N. Pham#, Amber N. Stratman, Daniel Castranova, Makoto Kamei, Kameha R. Kidd, Brigid D. Lo, Kenna M. Shaw, Jesus Torres-Vazquez, Constantinos M. Mikelis, Silvio J. Gutkind, George E. Davis, Brant M. Weinstein. CDP-diacylglycerolsynthetase-controlled phosphoinositide availability limitsVEGFA signaling and vascular morphogenesis. Blood 2012 Jul 12;120(2):489-498.
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