秦骏

秦骏

博士
肿瘤细胞可塑性研究组组长

邮箱: qinjun@sinh.ac.cn

电话: +86-21-54923326

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历

2017-至  今:中国科学院上海营养与健康研究所,研究员
2014-2016年:中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2012-2014年:美国贝勒医学院 助理教授
2005-2012年:美国贝勒医学院 博士后
2000-2005年:中国科学院上海生命科学研究院生化与细胞所 博士

研究方向

肿瘤细胞可塑性的表观遗传调控

研究内容

围绕肿瘤细胞可塑性的表观遗传调控,研究在肿瘤细胞转化及转分化中起关键作用的表观遗传调控因子,阐明其在相应病理转化过程中的作用机制。
(1)干细胞恶性转化、“惰性”肿瘤进展及内分泌治疗耐受的表观遗传调控机制
(2)肿瘤微环境重塑与表观遗传调控

代表论著(#第一作者,*通讯作者)

1. Peng S#, Wang Z#, Tang P#, Wang S#, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J*, Jiang J*, Liu Q*. PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma. Sci Adv 2023 Aug 2;9(31):eadf3566

2. Li N#*, Liu Q#, Han Y#, Pei S#, Cheng B, Xu J, Miao X, Pan Q, Wang H, Guo J, Wang X, Zhang G, Lian Y, Zhang W, Zang Y, Tan M, Li Q, Wang X, Xiao Y, Hu G, Jiang J*, Huang H*, Qin J*. ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression. Nat Commun 2022 Nov 26;13(1):7281

3. Ren J#, Li N#*, Pei S#, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y, Zhang G, Wang H, Li Y, Jiang J, Li Q, Tan M, Peng J, Hu G, Xiao Y, Li X*, Lin M*, Qin J*. Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity. J Clin Invest 2022 Apr 15;132(8):e153167

4. Jia P#, Li X#, Wang X#, Yao L, Xu Y, Hu Y, Xu W, He Z, Zhao Q, Deng Y, Zang Y, Zhang M, Zhang Y*, Qin J*, Lu W*. ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nat Commun 2021 Nov 11;12(1):6535

5. Pan Q, Zhong S, Wang H, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J*, Xiao Y*, Qin J*. The ZMYND8-regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability. Mol Cell 2021 Jul 1;81(13):2736-2751

6. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 2021 Jan;14(1):38-52

7. Liu Q, Pang J, Wang LA, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J*, Jiang J*. Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2. J Pathol 2021 Jan;253(1):106-118

8. Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X*, Jiang J*, Qin J*. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell 2020 Sep 14;38(3):350-365

9. Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019 Sep 25;10(1):4353

10. Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, Yuan H, Han Y, Chang H, Kan S, Wang X, Pan Q, Wu P, Peng C, Qiu T, Li Q, Gao D*, Xue W*, Qin J*. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest 2019 Feb 1;129(2):759-773

11. Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, Zhang L, Long X, Zhang Y, Cai Z, Zhai S, Qin J*, Wang X*. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Rep 2018 Dec 18;25(12):3393-3404

12. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018 May 7;215(5):1365-1382

13. Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M, Pan Q, Han Y, Wang X, Li Q, Qin J*. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest 2017 Sep 1;127(9):3375-3391

14. Li Y, Peng J, Sun T, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiaog Y, Wang X, Qin J*. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFa-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A 2017 May 9;114(19):E3796-E3805

15. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr;127(4):1284-1302

16. Qin J*, Lee HJ, Wu SP, Lin SC, Lanz Rb, Creighton CJ, DeMayo FJ, Tsai SY*, Tsai MJ*. Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. J Clin Invest 2014 Nov;124(11):5013-5026

17. Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann M, Tsai SJ, Tsai MJ*, Tsai SY*. COUP-TFII inhibits TGF-b-induced growth barrier to promote prostate Tumorigenesis. Nature 2013 Jan 10;493(7431):236-240