秦骏

秦骏

博士
肿瘤细胞可塑性研究组组长

邮箱: qinjun@sinh.ac.cn

电话: +86-21-54923326

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历

2017-至  今:中国科学院上海营养与健康研究所,研究员
2014-2016年:中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2012-2014年:美国贝勒医学院 助理教授
2005-2012年:美国贝勒医学院 博士后
2000-2005年:中国科学院上海生命科学研究院生化与细胞所 博士

研究方向

肿瘤细胞可塑性的表观遗传调控

研究内容

可塑性调控在药物抵抗和肿瘤转移中发挥着至关重要的作用,同时也是导致肿瘤异质性的主要原因之一。可塑性调控可被理解为细胞改变其身份的过程,包括同一谱系下细胞的分化,或者是细胞谱系的转分化或去分化(例如,针对肺癌和前列腺癌的靶向治疗导致下腺癌表型的转变为神经内分泌肿瘤,以及干细胞的恶性转化、肿瘤EMT和MET在肿瘤转移过程中的动态变化等)。进一步可塑性调控也可扩展至肿瘤整体表型的转变,例如惰性肿瘤的进展演化以及转移过程中肿瘤的休眠和苏醒等现象。
我们的研究以表观遗传调控与肿瘤细胞命运决定及微环境重塑为核心,聚焦前列腺癌及肠癌诊治中的临床重大需求,探究表观遗传调控在肿瘤转移及耐药中的功能,并基于此提出潜在的治疗策略;阐明表观遗传相关基因如何响应药物治疗、代谢、炎症等信号调控组蛋白修饰及染色质重塑进而决定肿瘤及微环境细胞的命运及功能。

代表论著(#第一作者,*通讯作者)

  1. Wang H#, Zhang S#, Pan Q#, Guo J, Li N, Chen L, Xu J, Zhou J, Gu Y, Wang X, Zhang G, Lian Y, Zhang W, Lin N, Jin Z, Zang Y, Lan W, Cheng X, Tan M, Chen F, Jiang J, Liu Q*, Zheng M*, Qin J*. Targeting ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation. Nature Cancer in press
  2. Dong B#, Xu J# *, Huang Y#, Guo J#, Dong Q#, Wang Y#, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J*, Xue W*, Tan M*, Qin J*. Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers. Nature Cancer 2024;5(9):1427-1447
  3. Long X#, Zhang S#, Wang Y#, Chen J#, Lu Y#, Hou H#, Lin B#, Li Q, Shen C, Yang R, Zhu H, Cui R, Cao D, Chen G, Wang D, Chen Y, Zhai S, Zeng Z, Wu S, Lou M, Chen J, Zou J, Zheng M*, Qin J*, Wang X*. Targeting JMJD1C to selectively disrupt tumor Treg fitness enhances anti-tumor immunity. Nature Immunology 2024;25,525–536
  4. Wang H#, Li N#, #, Liu Q#, Guo J, Pan Q, Cheng B, Xu J, Dong B, Yang G, Bin Yang B, Xuege Wang X, Gu Y, Zhang G, Lian Y, Zhang W, Zhang M, Li T, Zang Y, Tan M, Li Q, Wang W, Yu Z, Jiang J*, Huang H*, Qin J*. Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer. Cancer Cell 2023;41,1345–1362
  5. Chen M#, Wang K#, Han Y#, Yan S#, Yuan H, Liu Q, Li L, Li N, Zhu H, Lu D, Wang K, Fen Liu F, Luo D, Zhang Y, Jiang J, Li D, Zhang L, Ji H, Hu Zhou, Chen Y*, Qin J*, Gao D*. Identification of XAF1 as an endogenous AKT inhibitor. Cell Rep 2023;42(7):112690
  6. Peng S#, Wang Z#, Tang P#, Wang S#, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J*, Jiang J*, Liu Q*. PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma. Sci Adv 2023;9(31):eadf3566
  7. Li N#, Liu Q#, Han Y#, Pei S#, Cheng B, Xu J, Miao X, Pan Q, Wang H, Guo J, Wang X, Zhang G, Lian Y, Zhang W, Zang Y, Tan M, Li Q, Wang X, Xiao Y, Hu G, Jiang J*, Huang H*, Qin J*. ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression. Nat Commun 2022;13(1):7281
  8. Ren J#, Li N#, Pei S#, Lian Y, Li L, Peng Y, Liu Q, Guo J, Wang X, Han Y, Zhang G, Wang H, Li Y, Jiang J, Li Q, Tan M, Peng J, Hu G, Xiao Y, Li X*, Lin M*, Qin J*. Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity. J Clin Invest 2022;132(8):e153167
  9. Jia P#, Li X#, Wang X#, Yao L, Xu Y, Hu Y, Xu W, He Z, Zhao Q, Deng Y, Zang Y, Meiyu Zhang M, Zhang Y*, Qin J*, Lu W*. ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nat Commun 2021;12,6535
  10. Pan Q#, Zhong S#, Wang H#, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J*, Xiao Y*, Qin J*. The ZMYND8-regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability. Molecular Cell 2021;81(13):2736-2751
  11. Liu Q#, Pang J#, Wang LA#, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J*, Jiang J*. Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2. J Pathol 2021;253(1):106-118
  12. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 Restrains the Pro-Inflammatory Properties of ILC3s and Modulates Intestinal Immunity. Mucosal Immunol 2021;14(1):38-52
  13. Yuan H#, Han Y#, Wang X#, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X*, Jiang J*, Qin J*. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell 2020 14;38(3):350-365
  14. Yu T#, Gan S#, Zhu Q#, Dai D, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Luo X, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019;10(1):4353
  15. Ding Y#, Li N #, Dong B#, Guo W, Wei H, Chen Q, Yuan H, Han Y, Chang H, Kan S, Wang X, Pan Q, Wu P, Peng C, Qiu T, Li Q, Gao D*, Xue W*, Qin J*. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest 2019;129(2):759-773
  16. Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, Zhang L, Long X, Zhang Y, Cai Z, Zhai S, Qin J*, Wang X*. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Rep 2018 18;25(12):3393-3404
  17. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018;215(5):1365-1382
  18. Yuan H#, Li N#, Fu D#, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M, Pan Q, Han Y, Wang X, Li Q, Qin J*. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest 2017;127(9):3375-3391
  19. Li Y#, Peng J#, Sun T#, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiaog Y, Wang X, Qin J*. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNF-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A 2017;114(19):E3796-E3805
  20. Li N#, Xue W#, Yuan H#, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017;127(4):1284-1302
  21. Qin J*#, Lee HJ#, Wu SP, Lin SC, Lanz Rb, Creighton CJ, DeMayo FJ, Tsai SY*, Tsai MJ*. Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. J Clin Invest 2014;124(11):5013-26
  22. Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann M, Tsai SJ, Tsai MJ*, Tsai SY*. COUP-TFII inhibits TGF-b-induced growth barrier to promote prostate Tumorigenesis. Nature 2013;493(7431):236-240