张亮

张亮

博士
干细胞与发育研究组组长

邮箱: zhangliang01@sinh.ac.cn

电话: +86-21-54923250

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历


  2017-至  今:中国科学院上海营养与健康研究所 研究员
  2014-2016年:中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所-上海长征医院联合转化医学中心 研究员
  2008-2014年:美国洛克菲勒大学 博士后
  2002-2008年:美国科罗拉多大学博尔德分校 分子细胞及发育生物学系 博士
  2001-2002年:中国疾病预防控制中心 实习
  1997-2001年:北京大学生命科学学院 生物技术系 学士
  

研究方向

皮肤干细胞命运调控与病变

研究内容

  皮肤干细胞是皮肤生长发育/稳态维护/创伤修复的基础,其功能紊乱与脱发症、难愈创伤、皮肤癌等多种皮肤疾病的发生发展密切相关。本研究组致力阐明皮肤干细胞的命运调控与病变的分子机制,并以此为基础探索其在皮肤疾病创伤治疗/美容保健/组织工程中的应用。
  

代表论著(#第一作者,*通讯作者)

1. Sun Y*, Xu L*, Li Y*, Lin J, Li H, Gao Y, Huang X, Zhu H, Zhang Y, Wei K, Yang Y, Wu B, Zhang L#, Li Q#, Liu C#. Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy. Front Cell Dev Biol 2022 May 30;10:865983

2. Wu S*, Yu Y*, Liu CY*, Zhang X, Zhu PY, Peng Y, Yan XY, Li Y, Hua P, Li QF#, Wang S#, Zhang L#. Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying. Cell Discov 2022 May 24;8(1):49

3. Yu Y*, Zhang X, Liu FZ, Zhu PY, Zhang LP, Peng Y, Yan XY, Li Y, Hua P, Liu CY#, Li QF#, Zhang L#. A stress-induced miR-31–CLOCK–ERK pathway is a key driver and therapeutic target for skin aging. Nat Aging 2021 Sep;1(9):795-809 (Read fulltext at https://rdcu.be/cucwx)

4. Liu FZ*, Zhang X, Peng Y, Zhang LP, Yu Y, Hua P, Zhu PY, Yan XY, Li Y, Zhang L#. miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3. Cell Rep 2021 Jun 8;35(10):109225

5. Bao W*, Sun C*, Sun X, He M, Yu H, Yan W, Wen F, Zhang L#, Yang C#. Targeting BCL10 by small peptides for the treatment of B cell lymphoma. Theranostics 2020 Sep 19;10(25):11622-11636

6. Yang G*, Chen Q, Wen D, Chen Z, Wang J, Chen G, Wang Z, Zhang X, Zhang Y, Hu Q, Zhang L#, Gu Z#. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS Nano 2019 Apr 23;13(4):4354-4360

7. Wu S*, Zhang M*, Yang X*, Peng F, Zhang J, Tan J, Yang Y, Wang L, Hu Y, Peng Q, Li J, Liu Y, Guan Y, Chen C, Hamer MA, Nijsten T, Zeng C, Adhikari K, Gallo C, Poletti G, Schuler-Faccini L, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Gonzalez-Jose R, Li H, Krutmann J, Liu F, Kayser M, Ruiz-Linares A, Tang K, Xu S, Zhang L#, Jin L#, Wang S#. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet 2018 Sep 24;14(9):e1007640

8. Ge YJ*, Zhang L*, Nikolova M, Reva B, Fuchs E#. Strand-specific in vivo screen of 169 cancer-associated miRs unveils key drivers and oncogenic targets. Nat Cell Biol 2016 Jan;18(1):111-121

9. Zhang L*, Ge YJ, Fuchs E#. miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival. Genes Dev 2014 Nov 15;28(22):2532-2546 (Cover story)

10. Zhang L*, Stokes N, Polak L, Fuchs E#. Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment. Cell Stem Cell 2011 Mar 4;8(3):294-308 (Cover story)

11. Zhang L*, Hammell M, Kudlow BA, Ambros V, Han M#. Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development 2009 Sep;136(18):3043-3055

12. Zhang L*, Ding L*, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR 3rd, Han M#. Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2. Mol Cell 2007 Nov 30;28(4):598-613