周勇

周勇

博士
发育与疾病研究组组长

邮箱: zhouyong@sinh.ac.cn

电话: +86-21-54923289

所属部门: 中国科学院肿瘤与微环境重点实验室

个人简历

2017-至  今:中国科学院上海营养与健康研究所,研究员
2011-2016年:中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所,研究员
2008-2011年:哈佛医学院,马萨诸塞总医院,心血管研究中心(波士顿,美国),博士后研究员
2006-2008年:渥太华健康研究所,渥太华大学(渥太华,加拿大),博士后研究员
2001-2006年:中国海洋大学,海洋药物研究所,国家教育部海洋药物重点实验室(青岛),博士,药理学
2002-2006年:中国医学科学院北京协和医科大学,药物研究所(北京),博士联合培养,药理学
1997-2001年:中国海洋大学,药物化学专业,医学学士(青岛)

研究方向

血液与循环系统疾病研究

研究内容

1. 心脏的发生、再生与疾病的微环境研究:关注心脏形成的信号调控与先天性心脏病的致病机制,以及心肌梗死等的疾病微环境与再生治疗。
2. 血液的形成、分化与疾病的免疫微环境研究:关注造血干细胞形成及向免疫细胞、红细胞分化的信号调控,以及肿瘤相关的血液免疫微环境。

代表论著(#第一作者,*通讯作者)

1. Chu LM, Yin HM, Gao L, Xia Yu, Zhang CY, Chen Y, Liu TX, Huang JJ, Boheler KR, Zhou Y*, Yang HT*. Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Sci China Life Sci 2021 Feb;64(2):255-268

2. Hui-Min Yin, Li-Feng Yan, Qian Liu, Zheng Peng, Chi-Yuan Zhang, Yu Xia, Dan Su, Ai-Hua Gu*, Yong Zhou*. Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science Advances 2020 May 6;6(19):eaay9466

3. Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-Jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng*, Yong Zhou*, Shuhong Shen*. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica 2020 Apr;105(4):925-936

4. Zhang Chiyuan, Yin Huimin, Wang He, Su Dan, Xia Yu, Yan Lifeng, Fang Bin, Liu Wei, Wang Yumei, Gu Aihua*, Zhou Yong*. Transforming growth factor-β1 regulates the nascent hematopoietic stem cell niche by promoting gluconeogenesis. Leukemia 2018 Feb;32(2):479-491

5. Meng Zhaozheng, Liu Wei, Xia Yu, Yin Huimin, Zhang Chiyuan, Dan Su, Yan Lifeng, Gu Aihua*, Zhou Yong*. The pro-inflammatorysignalling regulator Stat4 promotes vasculogenesis of great vessels derivedfrom endothelial precursors. Nature Communications 2017 Mar 3;8:14640

6. X Peng, M Dong, L Ma, X-E Jia, J Mao, C Jin, Y Chen, L Gao, X Liu, K Ma, L Wang, T Du, Y Jin, Q Huang, K Li, LI Zon, T Liu, M Deng*, Y Zhou*, X Xi, Y Zhou*, S Chen*. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia 2015 Jan 1;29:2355-2365

7. Fan Hongbo, Liu Yijie, Wang Lei, Du Tingting, Gao Li, Meng Zhaozheng, Jin Yi, Chen Yi, Deng Min, Yang Huangtian, Jing Qing, Gu Aihua*, Zhou Yong*. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood 2014 Aug 21;124(8):1320-1330

8. Dong Zhiwei, Ren Chunguang, Su Dan, Du Tingting, Fan Hongbo, Yuan Hao, Wang Lei, Dong Mei, Li Weichun, Jin Yi, Chen Yi, Deng Min, Liu Tingxi, Gu Aihua*, Zhou Yong*. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology 2014 Mar 5;7(1):17-30

9. Wang Lei, Fu Cong, Fan Hongbo, Du Tingting, Dong Mei, Chen Yi, Jin Yi, Zhou Yi, Deng Min, Gu Aihua*, Jing Qing* Liu Tingxi, Zhou Yong*. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 2013 Jul 1;140(13):2755-2764

10. Gu Aihua*, Ji Guixiang, Yan Lifeng, Zhou Yong*. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair 2013 Dec 1;12(12):1094-1104

11. Jing Changbin, Chen Yi, Dong Mei, Peng Xiaolan, Jia Xiaoe, Gao Lei, Ma Ke, Deng Min, Liu Tingxi, Zon LI, Zhu Jun*, Zhou Yi, Zhou Yong*, Liu Yijie. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology 2013 Feb 1;374(1):24-31

12. Yan L#, Zhou Y#, Yu S, Ji G, Wang L, Liu W, Gu A. 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Exp Cell Res 2013;319(19):2954-2963

13. Zhou Y#, Cashman TJ, Nevis K, Obregon P, Carney SA, Liu Y, Gu AH, Mosimann C, Sondalle S, Peterson R, Heideman W, Burns CE, Burns CG. Latent TGF-b binding protein 3 identifies a second heart field in zebrafish. Nature 2011;474:645-648 (Highlighted)

14. Deacon DC, Nevis KR, Cashman TJ, Zhou Y, Zhao L, Washko D, Guner-Ataman B, Burns CG, Burns CE. The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis. Development 2010;137(11):1887-1896

15. Zhou Y#, Ma C, Karmouch J, Katbi HA, Liu XJ. Antiapoptotic role for ornithine decarboxylase during oocyte maturation. Mol Cell Biol 2009 Apr;29(7):1786-1795