全体研究组长

周犇
博士 研究员 博士生导师

能量代谢调控与衰老相关疾病研究组

研究方向:能量代谢调控、衰老与衰老相关疾病

电子邮件(E-mail):benzhou@sibs.ac.cn

电话(Tel):021-54920717

简历
2020-至  今:中国科学院上海营养与健康研究所 研究员
2013-2019年:哈佛医学院/麻省总医院 博士后
2006-2012年:中国科学院上海生命科学研究院营养科学研究所 博士
2002-2006年:南京大学生命科学学院 学士

研究内容
本课题组从衰老的几个重要表征如营养物质感应失调、线粒体功能障碍、表观遗传学改变以及蛋白质稳态丧失等出发,利用细胞,线虫和小鼠模型,综合应用基因编辑技术,蛋白质、脂质以及代谢产物组学技术等手段,对衰老各特征间的关联性进行功能和分子机制的深入解读,期望能够找到衰老的准确分子标志物并深入地理解衰老的的发生机制;通过大规模的遗传和小分子化合物的筛选,寻找并优化药物和营养干预衰老的新的靶点并促进健康老龄化。具体研究方向包括:(1)线粒体膜通透性与衰老和衰老相关疾病间的关系和机制研究;(2)细胞器/细胞核通讯与衰老和衰老相关疾病间的关系和机制研究;(3)mTORC2信号通路对营养感应、能量代谢和衰老的调控机制研究。

代表性论文(* 通讯作者)

  1. Zhou B*, Zhang Y, Li S, Wu L, Fejes-Toth G, Naray-Fejes-Toth A, Soukas AA. Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase. Cell Reports 2021 Oct 5;37(1):109785.
  2. Wang F, Dai Y, Zhu X, Chen Q, Zhu H, Zhou B, Tang H, Pang S. Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans. Nature communications 2021 Aug 20;12(1):5073.
  3. Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Cell 2019 Apr 4;177(2):299-314.e16.
  4. Zhou B, Soukas AA. Suppressing the dark side of autophagy. Autophagy 2019 Oct;15(10):1852-1853.
  5. Soukas AA, Zhou B. Surviving Starvation Simply Without TFEB. PLoS Biology 2019;17(5):e3000285.
  6. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Cedillo L, Kacergis MC, Sea CP, Soukas AA. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Report 2017 Jul 18;20(3):627-640.
  7. Wu L, Zhou B, Oshiro-Rapley N, Li M, Paulo JA, Webster CM, Mou F, Kacergis MC, Talkowski ME, Carr CE, Gygi SP, Zheng B, Soukas AA. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell 2016 Dec 15;167(7):1705-1718.e13.
  8. Liu J, Zhou B, Yan MH, Huang R, Wang YG, He ZS, Yang YG, Dai CG, Wang YQ, Zhang F, Zhai QW. CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice. Endocrinology 2016 Jun;157(6):2259-2269.
  9. Zhou B#, Zhang Y#, Zhang F#, Xia YL, Liu J, Huang R, Wang YG, Hu YN, Wu JX, Dai CG, Wang H, Tu YY, Peng XZ, Wang YQ, Zhai QW. CLOCK/BMAL1 regulates circadian change of insuin sensitivity via SIRT1. Hepatology 2014;59(6):2196-2206. (# equal contribution)
  10. Zhang Y#, Zhou B#, Deng B, Zhang F, Wu JX, Wang YG, Le YY, Zhai QW. Amyloid-β induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013 Apr;62(4):1159-1166 (# equal contribution)
  11. Wei HB#, Zhou B#, Zhang F, Tu YY, Zhang BG, Zhai QW. Profiling and identification of small rDNA-derived RNAs and their potential biological functions. PLoS One 2013;8(2):e56842. (# equal contribution)
  12. Zhou B#, Li C#, Qi W, Zhang Y, Zhang F, Wu JX, Hu YN, Wu DM, Liu Y, Yan TT, Jing Q, Liu MF, Zhai QW. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 2012 Jul;55(7):2032-2043. (# equal contribution)
  13. Zhang Y, Zhou B, Zhang F, Wu JX, Hu YN, Liu Y, Zhai QW. Amyloid-β induces insulin resistance by activating JAK2/STAT3/SOCS-1 signalling pathway. Diabetes 2012 Jun;61(6):1434-1443.