全体研究组长

邱菊
博士 研究员 博士生导师

中科院肿瘤与微环境重点实验室,炎症与免疫调节课题组组长

研究方向:粘膜免疫与天然淋巴细胞

电子邮件(E-mail):qiuju@sinh.ac.cn

电话(Tel):021-54923301

简历
2017-至  今:中国科学院上海营养与健康研究所 研究员
2014-2016年:中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 研究员
2009-2014年:西北大学Feinberg医学院 微生物与免疫学系 博士后
2009.04-2009.11:爱因斯坦医学院 细胞生物学系 博士后
2004-2009年:上海交通大学医学院 免疫学 医学博士
1999-2004年:泰山医学院(现山东第一医科大学)临床医学 学士

研究内容
天然淋巴细胞(Innate lymphoid cells, ILC)是一群谱系阴性(Lin-)、缺乏T、B细胞抗原特异性受体的天然免疫细胞亚群。ILC广泛存在于多种器官及粘膜组织,在感染性疾病、过敏性疾病、自身免疫病及肿瘤中发挥重要作用。我们利用炎症性疾病模型、细胞过继转移、细胞体外分化、多色流式及生物信息学等手段,主要研究调控ILC2和ILC3发育和功能的分子机制及对炎症性疾病的影响,以为诊断或治疗炎症性疾病提供理论依据和新手段。

代表性论文(*通讯作者)

  1. Jiali Chang, Xiaojuan Ji, Tian Deng, Jinxin Qiu, Zhaoyun Ding, Zhao Li, Yanhui Ma, Xiaoyu Hu, Li Li*, Ju Qiu*. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. Cell Rep 2022 Mar 15; https://doi.org/10.1016/j.celrep.2022.110530
  2. Jingjing Zhang#, Jinxin Qiu#, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He*, Ju Qiu*, Lei Shen*. Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity. Nat Immunol 2022 Feb;23(2):237-250.
  3. Qiu J#, Zhang J#, Ji Y*, Sun H#, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H*, Shen L*, Qiu J*. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol 2021 Nov;14(6):1306-1322
  4. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 2021 Jan;14(1):38-52
    Link: https://rdcu.be/b5mgc
  5. Deng T, Suo C, Chang J, Yang R, Li J, Cai T, Qiu J*. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol Immunol 2020 Feb;17(2):163-177
  6. Li J#, Shi W#, Sun H, Ji Y, Chen Y, Guo X, Sheng H, Shu J, Zhou L, Cai T, Qiu J*. Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. Nat Commun 2019 Jul 29;10(1):3371
  7. Ting Cai#, Jinxin Qiu#, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng*, Lei Shen*, Ju Qiu*. IL-17-producing-ST2+ILC2 plays a pathogenic role in lung inflammation. J Allergy Clin Immunol 2019 Jan;143(1):229-244
  8. Ye J#, Qiu J#, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep 2017 Nov 21;21(8):2277-2290
  9. Suo C, Fan Z, Zhou L, Qiu J*. Perfluorooctane sulfonate affects intestinal immunity against bacterial infection. Sci Rep 2017 Jul 12;7(1):5166
  10. Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu*, Yonghui Wang*. Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. Med Chem Commun 2016;7(12):2344-2348
  11. Qiu J, Zhou L. Aryl hydrocarbon receptor promotes RORγt(+) group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol 2013 Nov;35(6):657-670
  12. Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, Fu YX, Zhou L. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013 Aug 22;39(2):386-399
  13. Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2012 Jan 27;36(1):92-104