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全体研究组长

应浩
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室，副主任，甲状腺激素与代谢调控课题组组长

研究方向：内分泌代谢

电子邮件(E-mail)：yinghao@sibs.ac.cn

电话(Tel)：021-54920247

简历
2017-至　 今：中国科学院上海营养与健康研究所 研究员
2008-2016年：中国科学院上海生命科学研究院 营养科学研究所 研究员
2006-2008年：美国国家健康研究院国立癌症研究所 Staff Scientist
2001-2006年：美国国家健康研究院国立癌症研究所 博士后
1996-2001年：中国科学院上海细胞生物学研究所 博士
1992-1996年：华东理工大学生物工程系 学士

研究内容
1. 甲状腺激素及受其调控的非编码RNA在代谢调控中的作用
利用甲亢甲减及甲状腺激素受体敲除小鼠研究甲状腺激素调控网络中的非编码RNA，试图揭示这些非编码RNA是如何介导甲状腺激素对代谢的调控作用的。课题组近期筛选并研究了多个受甲状腺激素调控的微小RNA，揭示了这些miRNA对肝脏胰岛素信号通路、骨骼肌肌纤维分型和能源物质利用的调控作用及相关病理生理机制，发现多个潜在的药物干预靶点。
2. 甲状腺激素的非基因组作用在代谢调控中的作用
以受甲状腺激素调控的p38信号通路为突破口，研究甲状腺激素通过非基因组作用调控代谢的分子机制。课题组近期揭示p38可通过AMPK调控肝脏糖异生，发现抑制p38信号通路对白色脂肪米色化有促进作用，探索了多个潜在药物靶点治疗相关代谢性疾病的可行性。
3. 甲状腺肿瘤
建立甲状腺肿瘤小鼠模型，研究甲状腺肿瘤发生和发展的分子机制，发现甲状腺肿瘤的诊断标志物和潜在的药物靶点。

学术任职
中国生物化学与分子生物学会代谢专业委员会理事
中国生物物理学会脂代谢与生物能学分会理事
Biophysics Reports编委
Scientific Reports编委

代表性论文（* 通讯作者）

  1. Yuan F, Yin H, Deng Y, Jiao F, Jiang H, Niu Y, Chen S, Ying H, Zhai Q, Chen Y, Guo F. Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling. Mol Metab 2020 Dec;42:101084.
  2. Wei Y, Tian C, Zhao Y, Liu X, Liu F, Li S, Chen Y, Qiu Y, Feng Z, Chen L, Zhou T, Ren X, Feng C, Liu Y, Yu W, Ying H, Ding Q. MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism. Nat Metab 2020 May;2(5):447-460.
  3. Cheng Y, Liu J, Luan Y, Liu Z, Lai H, Zhong W, Yang Y, Yu H, Feng N, Wang H, Huang R, He Z, Yan M, Zhang F, Sun YG, Ying H, Guo F, Zhai Q. Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. Diabetes 2019 Nov;68(11):2120-2130.
  4. Li Y, Pan H, Zhang X, Wang H, Liu S, Zhang H, Qian H, Wang L, Ying H*. Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle. J Agric Food Chem 2019 Apr 24;67(16):4483-4492.
  5. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Cell Rep 2019 Jan 22;26(4):884-892.e4.
  6. Li Y, Jiang J, Liu W, Wang H, Zhao L, Liu S, Li P, Zhang S, Sun C, Wu Y, Yu S, Li X, Zhang H, Qian H, Zhang D, Guo F, Zhai Q, Ding Q, Wang L, Ying H*. microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10849-E10858.
  7. Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, Zhang H, Xu M, Rao Z, Wang L, Ying H*. Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells. Int J Biol Macromol 2018 Oct 1;117:287-293.
  8. Sun Y, Wang H, Li Y, Liu S, Chen J, Ying H*. miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-β/Smad Signaling Pathway in Skeletal Muscle Fibrosis. Mol Ther Nucleic Acids 2018 Jun 1;11:528-537.
  9. Zhang S, Cao H, Li Y, Jing Y, Liu S, Ye C, Wang H, Yu S, Peng C, Hui L, Wang YC, Zhang H, Guo F, Zhai Q, Wang H, Huang R, Zhang L, Jiang J, Liu W, Ying H*. Metabolic benefits of inhibition of p38α in white adipose tissue in obesity. PLoS Biol 2018 May 11;16(5):e2004225.
  10. Liu J, Zhang S, Cao H, Wang H, Sun C, Liu S, Yu S, Li Y, Liu W, Wang H, Jiang J, Ying H*. Deficiency of p38α in macrophage ameliorates d-galactosamine/TNF-α-induced acute liver injury in mice. FEBS J 2017 Dec;284(24):4200-4215
  11. Cao H, Zhang S, Shan S, Sun C, Li Y, Wang H, Yu S, Liu Y, Guo F, Zhai Q, Wang YC, Jiang J, Wang H, Yan J, Liu W*, Ying H*. Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation. J Biol Chem 2017 Nov 17;292(46):18973-18987.
  12. Zhang D, Li Y, Liu S, Wang YC, Guo F, Zhai Q, Jiang J, Ying H*. microRNA and thyroid hormone signaling in cardiac and skeletal muscle. Cell Biosci 2017 Mar 21;7:14.
  13. Zhang D, Li Y, Yao X, Wang H, Zhao L, Jiang H, Yao X, Zhang S, Ye C, Liu W, Cao H, Yu S, Wang YC, Li Q, Jiang J, Liu Y, Zhang L, Liu Y, Iwai N, Wang H, Li J, Li J, Li X, Jin ZB*, Ying H*. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle. Cell Rep 2016 Jul 19;16(3):757-768.
  14. Li Y, Zhang D, Wang X, Yao X, Ye C, Zhang S, Wang H, Chang C, Xia H, Wang YC, Fang J, Yan J, Ying H*. Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer. Sci Rep 2015 Jul 24;5:12495.
  15. Liu W, Cao H, Yan J, Huang R, Ying H*. 'Micro-managers' of hepatic lipid metabolism and NAFLD. Wiley Interdiscip Rev RNA 2015 Sep-Oct;6(5):581-593.
  16. Yao X, Sa R, Ye C, Zhang D, Zhang S, Xia H, Wang YC, Jiang J, Yin H*, Ying H*. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. Prostaglandins Other Lipid Mediat 2015 Apr-Jun;118-119:11-18
  17. Jing Y, Liu W, Cao H, Zhang D, Yao X, Zhang S, Xia H, Li D, Wang YC, Yan J, Hui L, Ying H*. Hepatic p38α regulates gluconeogenesis by suppressing AMPK. J Hepatol 2015 Jun;62(6):1319-1327.
  18. Zhang D, Wang X, Li Y, Zhao L, Lu M, Yao X, Xia H, Wang YC, Liu MF, Jiang J, Li X, Ying H*. Thyroid hormone regulates muscle fiber type conversion via miR-133a1. J Cell Biol 2014 Dec 22;207(6):753-766.
  19. Liu W, Cao H, Ye C, Chang C, Lu M, Jing Y, Zhang D, Yao X, Duan Z, Xia H, Wang YC, Jiang J, Liu MF, Yan J, Ying H*. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling. Nat Commun 2014 Dec 4;5:5684.
  20. Yao X, Hou S, Zhang D, Xia H, Wang YC, Jiang J, Yin H, Ying H*. Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. Cell Biosci 2014 Jul 30;4:38.
  21. Li X*, Li Y, Zhao L, Zhang D, Yao X, Zhang H, Wang YC, Wang XY, Xia H, Yan J, Ying H*. Circulating Muscle-specific miRNAs in Duchenne Muscular Dystrophy Patients. Mol Ther Nucleic Acids 2014 Jul 22;3(7):e177.
  22. Chen Z, Liu J, Fu Z, Ye C, Zhang R, Song Y, Zhang Y, Li H, Ying H*, Liu H*. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist. J Agric Food Chem 2014 Jul 2;62(26):6130-6137.
  23. Yao X, Xia H, Wang YC, Ying H*. Thyroid Hormone Receptor Coregulators in Metabolic Regulation. J Endocrinol Diabetes Obes 2014 Jul 19;2(3):1051.
  24. Wang YC, Li Y*, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H*. Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia 2013 Oct;56(10):2275-2285.
  25. Zhang D, Li X, Chen C, Li Y, Zhao L, Jing Y, Liu W, Wang X, Zhang Y, Xia H, Chang Y, Gao X, Yan J, Ying H*. Attenuation of p38-mediated miR-1/133 expression facilitates myoblast proliferation during the early stage of muscle regeneration. PLoS One 2012 Jul 24;7(7):e41478.
  26. Song Y, Shan S, Zhang Y, Liu W, Ding W, Ren W, Xia H, Li X, Zhang Q, Zhao L, Li X, Yan J, Ying H*. Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice. J Hepatol 2012 Jan;56(1):248-254.
  27. Yao X, Shan S, Zhang Y, Ying H*. Recent progress in the study of brown adipose tissue. Cell Biosci 2011 Oct 28;1:35.
  28. Song Y, Yao X, Ying H*. Thyroid hormone action in metabolic regulation. Protein Cell 2011 May;2(5):358-368.