1. English
  2. 中国科学院
  3. 邮箱登录
  4. ARP平台
 首页 > 人才队伍 > 全体研究组长
人才队伍

全体研究组长

胡国宏
博士 研究员 博士生导师

中科院肿瘤与微环境重点实验室，肿瘤转移课题组组长

研究方向：肿瘤转移与微环境调控

电子邮件(E-mail)：ghhu@sibs.ac.cn

电话(Tel)：021-54923296

传真(Fax)：021-54923297

简历
2017-至    今：中国科学院上海营养与健康研究所，研究员，院长助理
2009-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，研究员
2014-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，副所长
2011-2014年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，所长助理
2009-2009年：美国普林斯顿大学分子生物系，Associate Research Scholar
2005-2008年：美国普林斯顿大学分子生物系，博士后
2000-2005年：美国罗格斯大学，分子遗传学，博士
1996-2000年：清华大学，生物科学与技术系，学士

研究内容
1. 转移的微环境调控机制。肿瘤转移是癌症致死的主要原因。癌细胞对其所处微环境的适应及改造对转移过程有重要影响。我们主要研究癌细胞与转移微环境的互作机制，以及这些互作对肿瘤转移能力、转移的器官特异性、癌细胞的转移休眠/重激活状态的调控作用，并进一步发现有效预测肿瘤转移的分子标志物以及靶向肿瘤-微环境互作的策略。
2. 肿瘤干细胞与转移。肿瘤干细胞一般被认为是癌症发生、抗药及复发的“元凶”，但是肿瘤干细胞与转移的关系尚不清楚。我们主要研究肿瘤干细胞在转移中发挥的作用及调控机制，分析肿瘤干细胞的异质性，不同干细胞亚群的转移及调控，肿瘤干细胞与转移微环境的互作等，以期发现通过靶向肿瘤干细胞抑制转移的方法。
3. 肿瘤代谢调控与转移。肿瘤的Warburg效应已经引起广泛关注。我们主要研究在转移过程中的糖脂代谢调控，包括癌细胞自身的代谢异常模式、代谢微环境对癌细胞转移能力以及转移器官特异性的调控作用等。

代表性论文 (* 通讯作者)

  1. Xiao Y#, Cong M#, Li J, He D, Wu Q, Tian P, Wang Y, Yang S, Liang C, Liang Y, Wen J, Liu Y, Luo W, Lv X, He Y, Cheng DD, Zhou T, Zhao W, Zhang P, Zhang X, Xiao Y, Qian Y, Wang H, Gao Q, Yang QC, Yang Q, Hu G*. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 2020 Dec 31:S1535-6108(20)30660-30667
  2. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020 Sep 14;54(5):593-607
  3. Zhang P, Liu Y, Lian C, Cao X, Wang Y, Li X, Cong M, Tian P, Zhang X, Wei G, Liu T*, Hu G*. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Nat Commun 2020 May 19;11(1):2487
  4. Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H*, Hu R*, Hu G*. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination. Nat Cancer 2020 Jan 20;1(2):222-234
  5. Ma Q, Wu K, Li H, Li H, Zhu Y, Hu G, Hu L, Kong X. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep 2019 Dec 27;9(1):20021
  6. Zhuang X, Zhang H, Li X, Li X, Cong M, Peng F, Yu J, Zhang X, Yang Q*, Hu G*. Differential effects on lung and bone metastasis of breast cancer by Wntsignalling inhibitor DKK1. Nat Cell Biol 2017 Oct;19(10):1274-1285
  7. Huang H, Zhang W, Pan Y, Gao Y, Deng L, Li F, Li F, Ma X, Hou S, Xu J, Li P, Li X, Hu G, Li C, Chen H, Zhang L, Ji H*. YAP suppresses lung squamous cell carcinoma progression via deregulation of the DNp63-GPX2 axis and ROS accumulation. Cancer Res 2017 Nov 1;77(21):5769-5781
  8. Hu J#, Li G#, Zhang P, Zhuang X, Hu G*. A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 2017 Mar 16;8(3):e2679
  9. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr 3;127(4):1284-1302
  10. Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q*, Hu G*. The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 2017 Feb 16;36(7):989-998
  11. Yu PF, Huang Y, Xu CL, Lin LY, Han YY, Sun WH, Hu G, Rabson AB, Wang Y, Shi Y*. Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene 2017 Feb 9;36(6):840-849
  12. Yu J#, Lei R#, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G*. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 2016;7:13884
  13. Chen X, Cao X, Sun X, Lei, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, HouY, Wang M, SiebenlistUt, Chin E, Wang Y, Cao L, Hu G*, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 2016;7(12):e2508
  14. Liang Y#, Hu J#, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G*. Epigenetic activation of TWIST1 by MTDH promotes cancer stem-like Cell traits in breast cancer. Cancer Res 2015;75:3672
  15. Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G, Sun Y*. New horizons in tumor microenvironment biology: challenges and opportunities. BMC Medicine 2015;13:45
  16. Wei Q，Lei R, Hu G*. Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 2015;6;2-9
  17. Wan L, Hu G, Wei Y, Yuan M, Bronson RT, Yang Q, Siddiqui J, Pienta KJ, Kang Y*. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 2014;74(18):5336-5347
  18. Lin B#, Wang Y#, Wang Z, Tan H, Kong X, Shu Y, Zhang Y, Huang Y, Zhu Y, Xu H, Wang Z, Wang P, Ning G, Kong X*, Hu G*, Hu L*. Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 2014 Feb 28;9(2):e90215
  19. WangY, Lei R, Zhuang X, Zhang N, Pan H, Li G, Hu J, Pan X, Tao Q, Fu D, Xiao J, Chin E, Kang Y, Yang Q*, Hu G*. DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 2014;124(4):1646-1659
  20. Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q*. MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 2014;33(24):3119-3128
  21. Lei R#，Tang J#, Zhuang X, Deng R, Li G, Yu J, Liang Y, Xiao J, Wang H-Y, Yang Q, Hu G*. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 2014 Mar 6;33(10):1287-1296
  22. Zhang N, Wang X, Huo Q, Li X, Wang H-Y, Schneider P, Hu G*, Yang Q*. The oncogene metadherin modulates the apoptotic pathway based on thetumor necrosis factor superfamily member TRAIL in breast cancer. J Biol Chem 2013;288(13):9396-9407
  23. Liang Y, Wu H, Lei R, Chong RA, Wei Y, Lu X, Tagkopoulos I, Kung S-Y, Yang Q, Hu G*, Kang Y*. Transcriptional network analysis identifies BACH1 as amaster regulator of breast cancer bone metastasis. J Biol Chem 2012;287(40):33533-33544
  24. Jin L#, Zhang Y#, Li H, Yao L, Fu D, Yao X, Xu L*, Hu X*, Hu G*. Differential secretomeanalysis reveals CST6 as a suppressor of breast cancer bone metastasis. Cell Res 2012;22(9):1356-1373
  25. Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X*. ACAP4 cooperates with GRB2 to orchestrate EGF-stimulated integrin beta1 recycling in cell migration. J Biol Chem 2011;286(51):43735-43747
  26. Liang Y, Fu D, Hu G*. MTDH: An emerging key regulator of malignant progression in multiple cancers. Thorac Cancer 2011;2:143-148
  27. Korpal M, Ell B, Buffa F, Khan Z, Blanco M, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Singh M, Harris A, Kang Y*. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011;17(9):1101-1108
  28. Shan J#, Budijono S#, Hu G#, Yao N, Kang Y, Ju Y*, Prud’homme R*. PEGylated composite nanoparticles containing upconverting phosphors and meso-tetraphenylporphine (TPP) for photodynamic therapy. Adv Funct Mater 2011 May 5;21(13):2488-2495
  29. Lu X, Yan C, Yuan M, Wei Y, Hu G, Kang Y*. In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropicmetastasis of breast cancer. Cancer Res 2010;70(10):3905-3914