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 首页 > 人才队伍 > 全体研究组长

全体研究组长

詹丽杏
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室，肿瘤代谢及细胞极性的分子调控机制课题组组长

研究方向：肿瘤代谢及细胞极性的分子调控机制

电子邮件(E-mail)：lxzhan@sibs.ac.cn

电话(Tel)：021-54920978

简历
2017-至　 今：中国科学院上海营养与健康研究所 研究员
2010-2016年：中国科学院上海生命科学研究院营养科学研究所　研究员
2004-2010年：美国冷泉港实验室 博士后
1998-2003年：中国人民解放军第二军医大学 内科学专业 博士
1991-1996年：浙江医科大学 临床医学专业 学士

研究内容
1. 深入探讨上皮细胞中的极性基因功能以及在上皮屏障中的重要分子机制，上皮细胞命运调控过程中极性信号的关键机制，比如在自噬以及坏死性凋亡(necroptosis)中的调控机制，并探讨上皮细胞屏障破坏和和修复过程中极性基因的调控机制，以及上皮细胞屏障破坏与肿瘤发生的作用机制研究。
2. 以肿瘤原位移植技术结合生物信息学，分子生物学方法，获得肿瘤在肺部转移和定值中的关键分子节点，上皮细胞EMT和MET转化过程中极性信号的调控机制，以及在远端转移中的相关机制。
3. 以目前先进的类器官技术（organoid），进一步探讨上皮细胞稳态(Homeostasis)打破与损伤修复中极性通路的新功能，来研究肿瘤早期发生中与肿瘤微环境的相互作用，从而明确极性信号在决定上皮细胞命运以及异质性中的分子机制。

代表性论文（* 通讯作者）

  1. Song L#, Chang R#, Sun X, Lu L, Gao H, Lu H, Lin R, Xu X, Liu Z*, Zhan L*. Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice. Commun Biol 2021 Feb 16;4(1):213
  2. Wang N#, Song L#, Xu Y#, Zhang L, Wu Y, Guo J, Ji W, Li L, Zhao J, Zhang X*, Zhan L*. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. EBioMedicine 2019 Sep;47:65-77
  3. Dai C, Wang X, Wu Y, Xu Y, Zhuo S, Qi M, Ji W, Zhan L*. Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivity by Modulating IRS1/AKT Insulin Pathway in an SHP2-Dependent Manner. Diabetes 2019 Aug;68(8):1577-1590
  4. Chang R, Song L, Xu Y, Wu Y, Dai C, Wang X, Sun X, Hou Y, Li W, Zhan X, Zhan L*. Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis. Nat Commun 2018 Aug 28;9(1):3486
  5. Xiaojiao Li, Lele Song, Xingjie Hu, Chang Liu, Jiye Shi, Hui Wang*, Lixing Zhan*, Haiyun Song*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles. ACS Appl Mater Interfaces 2018 Jan 31;10(4):3449-3458
  6. Zheng Chao, Wang Yuetong, Yang Liu, Zhou Shuhua, Gao Yijun, Li Fuming, Feng Yan, Wang Zuoyun, Zhan Lixing, Yan Qin, Zhu Xueliang, Wong Kwok-Kin, Chen Zhengjun, Ji Hongbin*. Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis. Sci Rep 2017 Sep 4;7(1):10407
  7. Song Lele, Chang Renxu, Dai Cheng, Wu Yanjun, Guo Jingyu, Qi Meiyan, Zhou Wu*, Zhan Lixing*. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancerto chemotherapy drug. Oncotarget 2017 Feb 7;8(6):9108-9122
  8. Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH*. STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene 2016 Aug 18;35(33):4388-4398
  9. Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, Lin X, Feng XH*. Loss of α-Tubulin Acetylation isAssociated with TGF-β-induced EpithelialMesenchymal Transition. J Biol Chem 2016 Mar 4;291(10):5396-5405
  10. Zhou Y, Chang R, Ji W, Wang N, Qi M, Xu Y, Guo J, Zhan L*. Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance. J Biol Chem 2016 Jan 1;291(1):291-302
  11. Xu Yi, Chang Renxu, Peng Zhiyong, Wang Yanmei, Ji Weiwei, Guo Jingyu, Song Lele, Dai Cheng, Wei Wei, Wu Yanjun, Wan Xinjian, Shao Chenghao, Zhan Lixing*. Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression. Nat Commun 2015 May 26;6:7184
  12. Guo J, Xu Y, Ji W, Song L, Dai C, Zhan L*. Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicol Lett 2015 May 5;234(3):201-210
  13. Guo Jingyu, Wei Wei, Zhan Lixing*. Red and processed meat intake and risk of breast cancer:a meta-analysis of prospective studies. Breast Cancer Res Treat 2015 May;151(1):191-198
  14. Fatao Liu, Yi Zhou, Daizhan Zhou, Mengyuan Kan, Xiaomin Niu, Zhou Zhang, Di Zhang, Liming Tao, Lin He, Lixing Zhan*, Yun Liu*. Whole DNA methylome profiling in lung cancer cells before and after epithelial-to-mesenchymal transition. Diagn Pathol 2014 Mar 20;9:66
  15. Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR*. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol 2012 Jan 15;19(2):220-228