全体研究组长

翟琦巍
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室,副主任,营养与慢性代谢疾病研究组组长

研究方向:营养与慢性代谢疾病

电子邮件(E-mail): qwzhai@sibs.ac.cn

电话(Tel): 021-54920903

传真(Fax): 021-54920903

简历
2017-至  今:中国科学院上海营养与健康研究所 研究员
2004-2016年:中国科学院上海生命科学研究院营养科学研究所 研究员
2003-2004年:中国科学院上海生命科学院营养科学研究所 副研究员
2002-2003年:美国哈佛大学医学院儿童医院神经生物学系 博士后
2000-2002年:美国哈佛大学医学院病理系 博士后
1995-2000年:中国科学院上海生物化学研究所 生物化学与分子生物学 博士
1991-1995年:南京大学 生物化学 学士

研究内容
1. 从分子、细胞和动物水平研究各种营养因素对于肥胖、糖尿病、肿瘤和长寿的影响。
2. 研究乙酰化酶和去乙酰化酶及其调控因子、非编码核酸及其修饰等对肥胖、糖尿病和肿瘤的影响。
3. 通过高通量测序、基因编辑、代谢组学、蛋白质组学、修饰组学等新技术新方法,筛选和寻找能缓解肥胖、糖尿病和肿瘤或延长寿命的基因和药物。

学术任职
翟琦巍 任Journal of Molecular Endocrinology和Journal of Endocrinology编委
翟琦巍 任《生命科学》和《科技导报》编委
翟琦巍 中国生物化学与分子生物学会代谢专业委员会委员
翟琦巍 中国老年学和老年医学学会抗衰老分会委员

代表性论文(*通讯作者)

  1. Cheng Y, Liu J, Luan Y, Liu Z, Lai H, Zhong W, Yang Y, Yu H, Feng N, Wang H, Huang R, He Z, Yan M, Zhang F, Sun YG, Yin H, Guo F, Zhai Q*. Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. Diabetes 2019 Nov;68(11):2120-2130.
  2. Zhang F, Hao G, Shao M, Gedaa Hassan, An Y, Wang Q, Zhu Y, Christine M. Kusminski, Kien Nham, Rana K. Gupta, Zhai Q, Sun X, Philipp E. Scherer*, Orhan K. Oz*. An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents. Cell Metab 2018 Jan 9;27:252-262.
  3. Cao H, Zhang S, Shan S, Sun C, Li Y, Wang H, Yu S, Liu Y, Guo F, Zhai Q, Wang YC, Jiang J, Wang H, Yan J, Liu W, Ying H. Ligand-dependent corepressor (LCoR) represses the transcription factor C/EBPβ during early adipocyte differentiation. J Biol Chem 2017;292(46):18973-18987.
  4. Shan P, Fan G, Sun L, Liu J, Wang W, Hu C, Zhang X, Zhai Q, Song X, Cao L, Cui Y, Zhang S, Wang C. SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport. Curr Biol 2017 Aug;27(15):2271-2284.
  5. Luan Y, Zhang F, Cheng Y, Liu J, Huang R, Yan M, Wang Y, He Z, Lai H, Wang H, Ying H, Guo F, Zhai Q*. Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet. Nutrients 2017 Jul;9(8):805.
  6. Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Liu Z, Ying H, Liu Y, Zhai Q, Chen S, Guo F*. An ATF4/ATG5 signaling in hypothalamic POMC neurons regulates fat mass via affecting energy expenditure. Diabetes 2017;66(5):1146-1158.
  7. Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Chen S, Liu Z, Ying H, Liu Y, Zhai Q, Guo F*. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity. Autophagy 2017;13(6):1088-1089.
  8. Zhang D, Li Y, Liu S, Wang YC, Guo F, Zhai Q, Jiang J, Ying H*. microRNA and thyroid hormone signaling in cardiac and skeletal muscle. Cell Biosci 2017;7:14.
  9. Yan M, Zhai Q*. Sperm tsRNAs and acquired metabolic disorders. J Endocrinol 2016;230(3):F13-F18.
  10. Wang Y, Hu Y, Sun C, Zhuo S, He Z, Wang H, Yan M, Liu J, Luan Y, Dai C, Yang Y, Huang R, Zhou B, Zhang F, Zhai Q*. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy. FASEB J 2016;30(9):3133-3145.
  11. Liu J, Zhou B, Yan M, Huang R, Wang Y, He Z, Yang Y, Dai C, Zhang F, Zhai Q*. CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice. Endocrinology 2016;157(6):2259-2269.
  12. Chen Q*, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng G-h, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 2016;351(6271):397-400.
    Highligted by
    ① Leslie M. Sperm RNA fragments modify offspring metabolism. Science 2016;351(6268):13.
    ② Waldron D. Non-coding RNA: Inheritance of diet-induced metabolic changes via tsRNAs. Nat Rev Genet 2016;17(3):128.
    ③ Watson ED. Transferring Fragments of Paternal Metabolism to the Offspring. Cell Metab 2016;23(3):401-402.
    ④ Gapp K, Miska EA. tRNA fragments: novel players in intergenerational inheritance. Cell Res 2016;26(4):395-396.
  13. Li F, Han X, Li F, Wang R, Wang H, Gao Y, Wang X, Fang Z, Zhang W, Yao S, Tong X, Wang Y, Feng Y, Sun Y, Li Y, Wong KK, Zhai Q, Chen H, Ji H. LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response. Cancer Cell 2015;27(5):698-711.
  14. Zhou B, Zhang Y, Zhang F*, Xia Y, Liu J, Huang R, Wang Y, Hu Y, Wu J, Dai C, Wang H, Tu Y, Peng X, Wang Y, Zhai Q*. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1. Hepatology 2014;59(6):2196-2206.
  15. Ma C*, Yao M, Zhai Q, Jiao J, Yuan X, Poo M*. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development 2014;141(24):4697-4709.
  16. Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X*, Wang C*. The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab 2013;18(3):380-391.
  17. Yan M, Wang Y, Hu Y, Feng Y, Dai C, Wu J, Wu D, Zhang F, Zhai Q*. A high-throughput quantitative approach reveals more small RNA modifications in mouse liver and their correlation with diabetes. Anal Chem 2013;85(24):12173-12181.
  18. Zhang Y, Zhou B, Deng B, Zhang F, Wu J, Wang Y, Le Y*, Zhai Q*. Amyloid-β Induces Hepatic Insulin Resistance in vivo via JAK2. Diabetes 2013;62(4):1159-1166.
    Highlighted by Commentary: Sato N, Morishita R. Plasma Aβ: A Possible Missing Link Between Alzheimer Disease and Diabetes. Diabetes 2013;62(4):1005-1006.
    Highlighted by In this Issue of Diabetes: Resnick H. Blocking A Improves Insulin Sensitivity in AD Mouse Model. Diabetes 2013;62(4):1004.
  19. Zhang F, Xu X, Zhang Y, Zhou B, He Z, Zhai Q*. Gene expression profile analysis of type 2 diabetic mouse liver. Plos One 2013;8(3):e57766.
  20. Wei H, Zhou B, Zhang F, Tu Y, Hu Y, Zhang B, Zhai Q*. Profiling and Identification of Small rDNA-Derived RNAs and Their Potential Biological Functions. Plos One 2013;8(2):e56842.
  21. Liu A, Guo J, Liu W, Su F, Zhai Q, Mehta J, Wang W*, Su D*. Involvement of arterial baroreflex in the protective effect of dietary restriction against stroke. J Cereb Blood Flow Metab 2013;33(6):906-913.
  22. Zhang Y, Zhou B, Zhang F, Wu J, Hu Y, Liu Y, Zhai Q*. Amyloid-β induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 2012;61(6):1434-1443.
  23. Zhou B, Li C, Qi W, Zhang Y, Zhang F, Wu J, Hu Y, Wu D, Liu Y, Yan T, Jing Q, Liu M, Zhai Q*. Down regulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 2012;55(7):2032-2043.
  24. Feng Y, Wang Y, Wang Z, Fang Z, Li F, Gao Y, Liu H, Xiao T, Li F, Zhou Y, Zhai Q, Liu X, Sun Y, Bardeesy N, Wong KK, Chen H, Xiong ZQ, Ji H*. The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss. Cancer Res 2012;72(24):6502-6511.
  25. Liu Y, Zhou D, Zhang F, Tu Y, Xia Y, Wang H, Zhou B, Zhang Y, Wu J, Gao X, He Z, Zhai Q*. Liver Patt1 deficiency protects male mice from Age-associated but not high-fat diet-induced hepatic steatosis. J Lipid Res 2012;53(3):358-367.
  26. Wang P, Guan Y, Du H, Zhai Q, Su D*, Miao C*. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy 2012;8(1):77-87.
  27. Zhang F, Xu X, Zhou B, He Z, Zhai Q*. Gene Expression Profile Change and Associated Physiological and Pathological Effects in Mouse Liver Induced by Fasting and Refeeding. Plos One 2011;6(11):e27553.
  28. Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q*. WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis. Diabetes 2011;60(12):3197-3207.
  29. Yu Q, Wang T, Zhou X, Wu J, Chen X, Liu Y, Wu D, Zhai Q*. Wld Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD. PLoS One 2011;6(7):e21770.
  30. Wu D, Qiu Y, Gao X, Yuan XB, Zhai Q*. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function. PLoS One 2011;6(6):e21759.
  31. Wang P, Xu T, Guan Y, Tian W, Viollet B, Rui Y, Zhai Q, Su D*, Miao C*. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 2011;69(2):360-374.
  32. Hong Y, Chen Z, Zhang B, Zhai Q*. Isolation of Photobacterium sp. LuB-1 and its application in rapid assays for chemical toxicants in water. Lett Appl Microbiol 2010;51(3):308-312.
  33. Feng Y, Yan T, Zheng J, Ge X, Mu Yu, Zhang Y, Wu D, Du J, Zhai Q*. Overexpression of WldS or Nmnat2 in Mauthner cell by single-cell electroporation delays axon degeneration in live zebrafish. J Neurosci Res 2010;88(15):3319-3327.
  34. Yan T, Feng Y, Zhai Q*. Axon degeneration: Mechanisms and implications of a distinct program from cell death. Neurochem Int 2010;56(4):529-534. (Invited review)
  35. Feng Y, Yan T, He Z, Zhai Q*. WldS, Nmnats and Axon degeneration -progress in the past two decades. Protein & Cell 2010;1(3):237-245. (Invited review)
  36. Zheng J, Yan T, Feng Y, Zhai Q*. Involvement of lysosomes in the early stages of axon degeneration. Neurochem Int 2010;56(3):516-521.
  37. Jin Q*, Zhang F*, Yan T, Liu Z, Wang C, Ge X, Zhai Q*. C/EBPα Regulates SIRT1 Expression during Adipogenesis. Cell Res 2010;20(4):470-479.
  38. Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q*. Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int 2010 Jan;56(1):101-106.
  39. Xia YL, Zhai Q*. IL-1β enhances the antibacterial activity of astrocytes by activation of NF-κB. Glia 2010;58(2):244-252.
  40. Wang F, Gao Y, Zhang L, Bai B, Hu Y, Dong Z, Zhai Q, Zhu H, Liu J. A pair of windmill-shaped enantiomers from Lindera aggregata with activity toward improvement of insulin sensitivity. Org Lett 2010;12(14):3196-3199.