全体研究组长

冯英
博士 研究员 博士生导师

中科院营养代谢与食品安全重点实验室,代谢性疾病研究课题组组长

研究方向:可变剪接调控在代谢性疾病的调控研究

电子邮件(E-mail):fengying@sibs.ac.cn

电话(Tel):021-54920965

传真(Fax):021-54920965

简历
2017-至    今:中国科学院上海营养与健康研究所 研究员
2008-2016年:中国科学院上海生命科学研究院营养科学研究所 研究员
2008-2006年:哥伦比亚大学,Research Associate Scientist
2001-2006年:哥伦比亚大学博士后
1998-2001年:中科院上海生科院生化与细胞研究所 生物化学与分子生物学博士
1995-1998年:卫生部北京生物制品研究所 医学免疫学硕士

研究内容
长期致力于mRNA前体可变剪接精细调控的研究。利用敲除动物模型和细胞模型,结合高通量测序和生物信息学分析,深入研究可变剪接的精细调控机制以及剪接调控失常在发育或疾病包括肿瘤中的作用机理。

代表性论文(* 通讯作者)

  1. Guo R, You X, Meng K, Sha R, Wang Z, Yuan N, Peng Q, Li Z, Xie Z, Chen R*, Feng Y*. Single-cell RNA sequencing reveals heterogeneity of Myf5-derived cells and altered myogenic fate in the absence of SRSF2. Advanced Science 2022 Jun;9(18):e2105775.
  2. Sha R#, Wang Z#, You X, Liu Y, Xie Z, Feng Y*. Whole-mount Staining of Mouse Diaphragm Neuromuscular Junctions. Bio Protoc 2021 Nov 5;11(21):e4215.
  3. Liu Y, Luo Y, Shen L, Guo R, Zhan Z, Yuan N, Sha R, Qian W, Wang Z, Xie Z, Wu W*, Feng Y*. Splicing factor SRSF1 is essential for satellite cell proliferation and postnatal maturation of neuromuscular junctions in mice. Stem Cell Reports 2020 Oct 13;15(4):941-954.
  4. Zhang C, Shen L, Yuan W, Liu Y, Guo R, Luo Y, Zhan Z, Xie Z, Wu G, Wu W*, Feng Y*. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mic. Commun Biol 2020 May 5;3(1):210.
  5. Wang Q, Wang Y, Liu Y, Zhang C, Luo Y, Guo R, Zhan Z, Wei N, Xie Z, Shen L,Wu G, Wu W, Feng Y*. U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation. Int J Cancer 2019 Nov 15;145(10):2728-2739.
  6. Shen L, Han J, Wang H, Meng Q, Chen L, Liu Y, Feng Y* (co-corresponding), Wu G*. Cachexia-related long noncoding RNA, CAAlnc1, suppresses adipogenesis by blocking the binding of HuR to adipogenic transcription factor mRNAs. Int J Cancer 2019 Oct 1;145(7):1809-1821.
  7. Wu W*, Zong J, Wei N, Cheng J, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B, Feng Y*. CASH: a constructing comprehensive splice site method for detecting alternative splicing events. Brief Bioinform 2018 Sep 28;19(5):905-917.
  8. Liu L, Luo C, Luo Y, Chen L, Liu Y, Zhang Y, Xie Z, Wu W, Wu G*, Feng Y*. MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression. Oncogene 2018 Jan 4;37(1):86-94.
  9. Chen L, Luo C, Liu Y, Wang Q, Guo R, Zhang Y, Xie Z, Wei N, Wu W, Han J*, Feng Y*. SRSF1 prevents DNA damage and promotes tumorigenesis through regulating DBF4B pre-mRNA splicing. Cell Rep 2017 Dec 19;21(12):3406-3413.
  10. Wei N, Feng X, Xie Z, Zhang Y, Feng Y*. Long-term di (2-ethylhexyl)-phthalate exposure promotes proliferation and survival of HepG2 cells via activation of NFκB. Toxicol In Vitro 2017 Apr 13;42:86-92.
  11. Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z, Wu W, Feng Y*. SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Cancer Res 2017 Mar 1;77(5):1168-1178. CAN-16-1919
  12. Cheng Y, Luo C, Wu W, Xie Z, Fu X, Feng Y*. Liver-Specific Deletion of SC35/SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol 2016 May 16;36(11):1628-1638.
  13. Wei N, Cheng Y, Wang Z, Liu Y, Luo C, Liu L, Chen L, Xie A, Lu Y, Feng Y*. ASF/SRSF10 plays a role in myoblast differentiation and glucose production via regulation of alternative splicing. Cell Rep 2015 Nov 24;13(8):1647-1657.
  14. Zhou X,Li X,Cheng Y, Wu W, Xie Z, Xi Q, Han J, Wu G, Fang J, Feng Y*. BCLAF1 and its splicing regulator SRSF10 regulate tumorigenic potential of colon cancer cells. Nat Commun 2014 Aug 5;5:4581.
  15. Li H,Cheng Y,Wu W, Liu Y, Wei N,Feng X, Xie Z, Feng Y*. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol Cell Biol 2014 Jun 15;34(12):2198-2207.
  16. Zhou X, Wu W, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y*. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res 2014 Apr;42(6):4019-4030.
  17. Zhou X, Wu W, Wei N, Cheng Y, Xie Z, Feng Y*. Genome-wide analysis of SRSF10-regulated alternative splicing by deep sequencing of chicken transcriptome. Genomics Data 2014 Mar 12;2:20-23.
  18. Li H,Wang Z, Zhou X, Cheng Y, Xie Z, Manley JL, Feng Y*. Binding of FUBP1 to an exonic splicing silencer and RNA secondary structure mediate second-step splicing repression. Proc Natl Acad Sci U S A 2013 Jul 16;110(29):E2687-E2695.