全体研究组长

杨黄恬
医学博士 研究员 博士生导师

中科院肿瘤与微环境重点实验室分子心脏学课题组组长

电子邮件(E-mail):htyang@@sibs.ac.cn

简历 & 研究方向
2017-至  今 中国科学院上海营养与健康研究院 研究员
2000-2016年 中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 研究员
2005-2014年 中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 副所长
2003-2004年 中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 所长助理
1997-2001年 美国国立卫生研究院/老年研究所(NIH/NIA)心血管研究室/分子心脏学室Research fellow
1992-1997年 日本山形大学医学部药理教研室客座研究员、助手
1992-1994年 日本山形大学医学部医学博士
1988-1992年 南通医学院药理教研室助教、讲师
1985-1988年 苏州医学院医学硕士
1982-1985年 南通医学院药理教研室助教
1978-1982年 南通医学院医学系医学学士

学术任职
国际心脏研究学会(ISHR)中国分会执委会副主席
国际心脏研究会中国转化医学工作委员会常务委员
中国病理生理学会心血管专业委员会委员
中国病理生理学会受体与信号转导专业委员会委员
中国药理学会心血管药理专业委员会委员
中国生理学会循环生理专业委员会委员
中国细胞生物学学会常务理事
中华医学会心血管病学分会第十届委员会委员
上海细胞生物学学会副理事长
国际干细胞研究学会会员
美国心脏学会Professional会员
Acta Pharmacol Sinica编委
AJP-Heart and Circulatory Physiology 编委
Cardiovascular Drugs and Therapy编委
Cell Death & Diseases编委
Frontier in Pharmacology编委中国细胞生物学学报 编委
J Mol Cell Cardiol 副主编
Pflügers Archiv - European Journal of Physiology 副主编
中国应用生理学杂志 编委
中国分子心脏病学杂志 编委

研究方向
冠状动脉病变引发的心肌梗死等缺血性心脏病及由此发生的心力衰竭已成为心血管疾病主要致死原因。及时疏通狭窄或阻塞的冠状动脉,使缺血心肌获得血液再灌注是治疗缺血性心脏病的根本策略,但再灌注本身也会造成额外的损伤;同时心肌梗死造成的大量心肌细胞的死亡为纤维疤痕替代,进而导致心功能不全。因此,逆转急性心梗期心肌细胞的“减容”是抑制纤维瘢痕形成、最大限度保留心脏功能、制约心力衰竭发生发展链、降低心肌梗死死亡率的关键环节。针对这些临床问题,课题组研究聚焦于揭示心脏收缩功能调控和缺血后心力衰竭发生发展和保护的细胞分子机理, 探寻防治缺血性心脏病的有效靶点和手段。目前研究主要集中在如下方面:
1. 多能干细胞心肌细胞分化的调控、高效分化方法的建立和心肌修复与再生
2. 心肌钙信号网络及G蛋白耦联受体介导的信号通路在心肌发育、保护和收缩中的调控;
3. 间歇性低氧适应、天然物质及内源性物质的心肌保护作用、细胞分子机制及应用转化研究。

代表性论文(* 通讯作者)

  1. Huang C, Tu W, Fu Y, Wang J, Xie X. Chemical-induced cardiac reprogramming in vivo. Cell Res. 2018;28(6):686-9. doi: 10.1038/s41422-018-0036-4.
  2. Wang X, Wang L, Wu Q, Bao F, Yang HT*, Qiu X*, & Chang J*. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure. ACS applied materials & interfaces, 2019;11(1):1449-1468. doi: 10.1021/acsami.8b17754.
  3. Wang JX, Liu ML, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin Y, Paul C, Wang Y, Yang HT*. Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6. Antioxid Redox Signal. 2019 Mar 11. doi: 10.1089/ars.2018.7688. [Epub ahead of print]
  4. Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT*. Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A. Acta Pharmacol Sin. 2019 Mar 11. doi: 10.1038/s41401-018-0197-1 [Epub ahead 2019 Apr 16. doi: 10.1089/ars.2018.7688. [Epub ahead of print].
  5. Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680. doi: 10.1073/pnas.1821022116.
  6. Tan JL, Shanshan Gu, Yanjun Zheng, Yang HT. Expression Profile of Circular RNAs in Myocardial Ischemia/Reperfusion with and without Intermittent Hypobaric Hypoxia Preconditioning. SCIENCE CHINA LIFE SCIENCE. doi:10.1007/s11427-018-9478-0
  7. Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates. Circ Res. 2018 Mar 30;122(7):958-969. doi: 10.1161/CIRCRESAHA.117.311578.
  8. Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT*. IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol. 2017 2017 Aug 1;9(4):274-288. doi: 10.1093/jmcb/mjx014. (cover article)
  9. Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT*. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int. 2017;2017:1769298. doi: 10.1155/2017/1769298.
  10. Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017 Feb 2;8(2):e2577. doi: 10.1038/cddis.2017.7.
  11. Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A. 2017 Jan 13. doi: 10.1002/jbm.a.36005.
  12. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016;22(10):1131-1139.
  13. Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP3 receptors mediates differential Ca2+ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-78.
  14. Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells. 2016 Jun;34(6):1527-40.
  15. Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015 Apr;81:150-61.
  16. Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res. 2015 Feb 1;105(2):192-202.
  17. Ling Gao, Yan-Jun Zheng, Shan-Shan Gu, Ji-Liang Tan, Christian Paul, Yi-Gang Wang, Huang-Tian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014 Dec;77:102-112.
  18. Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis. 2014 Jun 19;5:e1297.
  19. Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul;35(7):899-906.
  20. Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1569-81.
  21. Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 2013 Sep;23(9):1119-32.
  22. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca2+ Homeostasis and Preventing Calpain Activation. Circ J. 2012;76(8):1993-2002.
  23. Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol. 2012 Oct;97(10):1105-18.
  24. Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang H*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-37.
  25. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 2012 Jan;22(1):219-36.
  26. Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1695-705.
  27. Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca2+-independent Mechanism. J Cardiovasc Pharmacol. 2011 Jul;58(1):40-8.
  28. Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res. 2011 Sep;21(9):1316-31. doi: 10.1038/cr.2011.48.
  29. Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 May;106(3):329-42.
  30. Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT*. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010 Jul;17(7):1141-54.
  31. Yu Z, Wang ZH, Yang HT*. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H735-42.
  32. Guo A, Yang HT*. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. Am J Physiol Cell Physiol. 2009 Sep;297(3):C732-41.
  33. Yang WW, Shu B, Zhu Y, Yang HT*. E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced Apoptosis through E2F1. Mol Biol Cell. 2008 Sep;19(9):3691-700. (cover article)
  34. Xi-Yuan Lu, Le Chen, Xiao-Long Cai, Huang-Tian Yang*. Overexpression of heat shock protein 27 against ischemia/reperfusion-induced cardiac contractile dysfunction via stabilization of troponin I and troponin T. Cardiovasc Res. 2008 Aug 1;79(3):500-8.
  35. Hui-Mei Yu, Jing Wen, Rong Wang, Wan-Hua Shen, Shumin Duan, Huang-Tian Yang*. Critical role of type 2 ryanodine receptor in mediating activing-depent neurogensis from embryonic stem cells. Cell Calcium. 2008 Jun;43:417-431.
  36. Rong Wang, Ji Liang, Lianju Qin and Huang-Tian Yang*. Promoter-dependent EGFP expressions during embryonic stem cell propagation and differentiation. Stem Cells Dev. 2008 Apr;17(2):279-89.
  37. Shu B, Yang WW, Yang HT*. Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis. Sheng Li Xue Bao. 2008 Feb 25;60(1):1-10.
  38. Gao H, Chen L, Yang HT*. Activation of alpha(1B)-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca(2+) overload in cardiomyocytes. Cardiovasc Res. 2007 Aug 1;75(3):584-95.
  39. Li J, Zhang H, Zhu WZ, Yu Z, Guo A, Yang HT*, Zhou ZN. Preservation of the pHi during ischemia via PKC by intermittent hypoxia. Biochem Biophys Res Commun. 2007 May 4;356(2):329-33.
  40. Yang WW, Wang ZH, Zhu Y, Yang HT*. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ. 2007 Apr;14(4):807-817.
  41. Jidong Fu, Huimei Yu, Rong Wang, Ji Liang, Huangtian Yang*. Developmental regulation of intracellular calcium transients during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2006 Jul;27(7):901-10.
  42. Le Chen, Xi-Yuan Lu, Jun Li, Ji-Dong Fu, Zhao-Nian Zhou, Huang-Tian Yang*. Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. Am J Physiol Cell Physiol. 2006 Apr;290(4):C1221-9.
  43. Jidong Fu, Jun Li, David Tweedie, Huimei Yu, Le Chen, Rong Wang, Daniel R. Riordon, Sheryl A. Brugh, Shiqiang Wang, Kenneth R. Boheler, Huangtian Yang*. Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells. FASEB J. 2006 Jan;20(1):181-3.
  44. Zhang FB, Li L, Fang B, Zhu DL, Yang HT*, Gao PJ*. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun. 2005 Oct 28;336(3):784-92.
  45. Xie Y, Zhu Y, Zhu WZ, Chen L, Zhou ZN, Yuan WJ, Yang HT*. Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H2594-602.
  46. Yan Xie, Weizhong Zhu, Zhaonian Zhou, Zhu Yi, Huangtian Yang*. Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. Life Sci. 2004 Dec 17;76(5):559-72.
  47. Anna M. Wobus, K Guan, Huang-Tian Yang, Kenneth R. Boheler. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods in Molecular Biology. 2002;185:127-156.
  48. Huang-Tian Yang*, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta and Kenneth R. Boheler. The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development. Proc Natl Acad Sci USA. 2002;99:9225-9230.
  49. Huangtian Yang*, Kiyoharu sakurai, Hiromi Sugawara, Tomoo Watanabe, Ikuo Norota, Masao Endoh. Contribution of Na+/Ca2+ exchange to the endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular cardiac myocytes: pharmacological analysis with KB-R7943. Br J Pharmacol. 1999;126:1785-1795.
  50. Y Zhu, HT Yang, M Endoh. Does nitric oxide contribute to the negative choronotropic and inotropic effects of endothelin-1 in the heart? Eur J Pharmacol. 1997;332:195-199.
  51. Huang-Tian Yang & Masao Endoh. Pharmacological evidence for a1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br J Pharmacol. 1997;122:1541-1550.
  52. Yi Zhu, Huang-Tian Yang and Masao Endoh. Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle. Am J Physiol. 1997;273(42):H119-H127.
  53. Huang-Tian Yang, Yi Zhu and Masao Endoh. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in relation to specific binding sites in mammalian ventricular myocardium. Br J Pharmacol. 1997;120:1497-1504.
  54. Huang-Tian Yang & Masao Endoh. (±)-Tamsulosin, an a1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol. 1996;312(3):281-291.
  55. Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Methoxamine-induced inhibition of the positive inotropic effect of endothelin via a1-adrenoceptors in the rabbit heart. Eur J Pharmacol. 1996;296(1):47-54.
  56. Huang-Tian Yang, Ikuo Norota, Yi Zhu and Masao Endoh. Mechanisms for the inhibitory action of methoxamine on the receptor-mediated inotropic response. Heart. 1995;27(2):16-19.
  57. Huang-Tian Yang, Ikuo Norota and Masao Endoh. Positive inotropic effect and acceleration of phosphoinositide hydrolysis by methoxamine. Heart. 1994;26(4):24-28.
  58. Yang Huang-Tian, Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 1994;10:411-414.
  59. Huang-Tian Yang and Masao Endoh. Dissociation of the methoxamine-induced positive inotropic effect and phosphoinositide hydrolysis in rabbit ventricular myocardium: comparison with phenylephrine and alpha-1 adrenoceptor subtype involved. J Pharmacol Exp Ther. 1994;269(2):732-742.
  60. Kohi M, Yang HT, Endoh M. Myocardial a 1A-adrenoceptor subtypes in rabbit: differentiation by a selective antagonist, HV723. Eur J Pharmacol. 1993;250:95-101.
  61. Yang Huang-Tian, Yang Yu-Lin, Peng Si-Xun, Huang Wen-Long. Hypotensive effect of naphthylmethyl isoquinoline. Acta Pharmaceutica Sinica. 1990;25(7):551-554.
  62. Yang Huang-Tian, Yang Yu-Lin. Effect of naphthylmethyl isoquinoline on the isolated guinea pig myocardium. Acta Pharmaceutica Sinica. 1990;25(7):485-489.

评述与综述

  1. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.
  2. Wu Q, Yang HT*. Roles of Exosomes Secreted from Stem Cells and Their Derived Cells in Cardiac Repair Following Myocardial Infarction. Chinese Journal of Cell Biology 中文版本. 2018;40(13):2198-2208. doi: 10.11844/cjcb.2018.13.0008.
  3. Xinyang Hu, HuangTian Yang, Yuangui Zhu, Jian'an Wang, Erdan Dong. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016;118(12):1876-9. doi: 10.1161/CIRCRESAHA.116.308063. (viewpoint)
  4. Yang HT*, Zhang M, Huang JJ, Liang H, Zhang P, Boheler KR. Cardiomyocytes derived from pluripotent stem cells: progress and prospects from China. Exp Cell Res. 2013;319(2):120-5. doi: 10.1016/j.yexcr.2012.09.011.
  5. Feng Y, Wang Y, Cao N, Yang H, Wang Y*. Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope? Ann Palliat Med. 2012;1(1):65-77.
  6. Yang HT*. Adaptation to Intermittent Hypoxia Protects the Heart from Ischemia/Reperfusion Injury and Myocardial Infarction. Science 2012.P47-48.
    http://www.sciencemag.org/site/products/index.xhtml
  7. 梁贺, 王嘉, 曹楠, 黄吉均, 杨黄恬*. 胚胎干细胞及诱导多能干细胞向心肌细胞分化和调控的研究进展. 生命科学. 2009;21(5):663-668.
  8. Huang-Tian Yang and Chao-Shu TAN. Spotlight on cardioprotection against ischemia-reperfusion injury (Editorial Comment). Acta Physiologica Sinica Special Issue on Cardiovascular Injury and Protection. 2007;59(5):540-541.
  9. Zhang Yi, Yang HT, Zhou ZN. The Cardioprotection of intermittent hypoxic adaptation. Acta Physiologica Sinica. 2007;59(5):601-613.
  10. Ji-Dong Fu, Huang-Tian Yang*. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Acta Physiologica Sinica, 2006;58(2):95-103.
  11. Zhang FB, Yang HT*. Plasticity of bone marrow mesenchymal stem cells differentiating into cardiomyocytes and the potential of cardiac therapeutics. Progress in Physiological Sciences. 2006;37(3):199-204.
  12. Yang HT. Stem Cells. Science (Chinese) 2005;57(5):54-55.
  13. Yang HT. Stem Cells: Hot Field in life science. Science (Chinese) 2002;54(3):12-14.
  14. KR Boheler, J Czyz, D Tweedie, Huang-Tian Yang, Anisimov SV, Wobus AW. Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ Res, 2002;91:189-201.
  15. Endoh M, Maruya J, Norota I, Yang HT, Talukder M A, Hassan, Watanabe T, Sakurai K. Cardiac effects of endothelin: difference between signals in myocytes and intact ventricular myocardium. Current Topics in Pharmacology. 1998;4:293-300.
  16. Yang Huang-Tian, Yang Yu-Lin. Study of alpha-1 adrenoceptors in heart: mechanisms of positive inotropic effects and receptor subtypes. Chinese Pharmacological Bulletin. 1994;10:411-414.

专著

  1. 杨黄恬, 黄吉均, 郑严俊. 《疾病机制》(第1版)人民卫生出版社. 主编: 王建枝 吴立玲 陈琪; 第19章, 细胞治疗; ISBN 978-7-117-27283-4;323-330;2019.01
  2. 张敏, 高崚, 王志华, 杨黄恬*. 总论《中华医学百科全书—基础医学人体生理学》(Medical Encyclopedia of China), 主编唐朝枢. 中国协和医科大学出版社, 2017.7 ISBN 978-7-5679-0668-6
  3. Nan Cao, He Liang, Huang-TianYang*. Generation, Expansion, and Differentiation of Cardiovascular Progenitor Cells from Human Pluripotent Stem Cells. Edited by Kursad Turksen, Ph.D., Cell-Cell Communications in Stem Cell Renewal: Methods Mol Biol. published by Springer 2015;1212:113-25. doi: 10.1007/7651_2014_119.
  4. Yang HT*, Yi Zhang, Wang ZH and Zhou ZN. Chapter 4. Protective effects of chronic intermittent hypoxia against myocardial ischemia/reperfusion injury, p47-58 in the book Intermittent hypoxia and human diseases, Edited by Dr. Lei Xi and Dr. Tatiana V. Serebrovskaya, published by Springer (http://www.springerlink.com/content/978-1-4471-2905-9/?MUD=MP) in 2012.
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