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 首页 > 人才队伍 > 全体研究组长

全体研究组长

秦骏
博士 研究员 博士生导师

中国科学院肿瘤与微环境重点实验室，肿瘤细胞可塑性课题组组长

研究方向：肿瘤细胞可塑性的表观遗传调控

电子邮件(E-mail)：qinjun@sibs.ac.cn

电话(Tel)：021-54923326

简历
2017-至　 今：中国科学院上海营养与健康研究所，研究员
2014-2016年：中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所 研究员
2012-2014年：美国贝勒医学院 助理教授
2005-2012年：美国贝勒医学院 博士后
2000-2005年：中国科学院上海生物化学与细胞生物学研究所 博士

研究内容
围绕肿瘤细胞可塑性的表观遗传调控，研究在肿瘤细胞转化及转分化中起关键作用的表观遗传调控因子，阐明其在相应病理转化过程中的作用机制。
（1）干细胞恶性转化、“惰性”肿瘤进展及内分泌治疗耐受的表观遗传调控机制
（2）肿瘤微环境重塑与表观遗传调控

代表性论文（*通讯作者）

  1. Pan Q, Zhong S, Wang H, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J*, Xiao Y*, Qin J*. The ZMYND8-regulated Mevalonate Pathway Endows YAP-High Intestinal Cancer with Metabolic Vulnerability. Mol Cell 2021 Apr 22;S1097-2765(21)00314-2. doi: 10.1016/j.molcel.2021.04.009
  2. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 2021 Jan;14(1):38-52
  3. Liu Q, Pang J, Wang LA, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J*, Jiang J*. Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2. J Pathol 2021 Jan;253(1):106-118
  4. Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X*, Jiang J*, Qin J*. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell 2020 Sep 14;38(3):350-365
  5. Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019 Sep 25;10(1):4353
  6. Ding Y, Li N, Dong B, Guo W, Wei H, Chen Q, Yuan H, Han Y, Chang H, Kan S, Wang X, Pan Q, Wu P, Peng C, Qiu T, Li Q, Gao D*, Xue W*, Qin J*. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. J Clin Invest 2019 Feb 1;129(2):759-773
  7. Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, Zhang L, Long X, Zhang Y, Cai Z, Zhai S, Qin J*, Wang X*. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Rep 2018 Dec 18;25(12):3393-3404
  8. Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018 May 7;215(5):1365-1382
  9. Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M, Pan Q, Han Y, Wang X, Li Q, Qin J*. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest 2017 Sep 1;127(9):3375-3391
  10. Li Y, Peng J, Sun T, Li N, Zhang L, Ren J, Yuan H, Kan S, Pan Q, Li X, Ding Y, Jiang M, Cong X, Tan M, Ma Y, Fu D, Cai S, Xiaog Y, Wang X, Qin J*. Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFa-mediated inflammation and apoptosis. Proc Natl Acad Sci U S A 2017 May 9;114(19):E3796-E3805
  11. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, Jiang M, Kan S, Sun T, Ren J, Pan Q, Li X, Zhang P, Hu G, Wang Y, Wang X, Li Q, Qin J*. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 2017 Apr;127(4):1284-1302
  12. Qin J*, Lee HJ, Wu SP, Lin SC, Lanz Rb, Creighton CJ, DeMayo FJ, Tsai SY*, Tsai MJ*. Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. J Clin Invest 2014 Nov;124(11):5013-5026
  13. Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann M, Tsai SJ, Tsai MJ*, Tsai SY*. COUP-TFII inhibits TGF-b-induced growth barrier to promote prostate Tumorigenesis. Nature 2013 Jan 10;493(7431):236-240