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 首页 > 人才队伍 > 全体研究组长

全体研究组长

章海兵

中科院营养代谢与食品安全重点实验室，细胞死亡与免疫代谢课题组组长

研究方向：细胞死亡与免疫代谢

电子邮件(E-mail)：hbzhang@sibs.ac.cn

电话(Tel)：021-54920988

简历
2017–至　 今：中国科学院上海营养与健康研究所 研究员
2013-2016年：中国科学院上海生命科学研究院营养科学研究所 研究员
2012-2013年：费城儿童医院 博士后
2006-2012年：托马斯杰弗逊大学 博士后
2000-2006年：中科院上海生命科学研究院健康研究所 博士
1993-1997年：山东大学 微生物系

研究内容
细胞死亡是维持多细胞生命活动的基础，过多或过少的细胞死亡都会引起疾病的发生。细胞死亡主要包括细胞凋亡和细胞坏死，而近年发现的细胞程序性坏死（Necroptosis）是由包含RIP1/RIP3/MLKL的坏死复合物精密调控的一种重要细胞坏死形式，并且显示细胞程序性坏死通过多种途径参与炎症信号的调控。本研究组主要研究细胞程序性坏死与炎症的调控机制，及在相关代谢性疾病中的作用机理。通过探索细胞程序性坏死、炎症与代谢性疾病之间的作用关系，为相关疾病的防治提供理论依据。

代表性论文（*通讯作者, #共同一作）

  1. Li M, Liu Y, Xu C, Zhao Q, Liu J, Xing M, Li X, Zhang H, Wu X, Wang L, Ou Y, Wu X, Zhao X, Liu H, Qiu L, Li F, Li J, Rong W, Luo Y, Deng J, Wang X, Wang Z, Zhao Y, Lv A, Li Q, Zhang H*. Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development. Cell Death Differ 2022 Apr 16. doi: 10.1038/s41418-022-00994-1.
  2. Li X#, Li F#, Zhang X, Zhang H, Zhao Q, Li M, Wu X, Wang L, Liu J, Wu X, Ou Y, Xing M, Zhang Y, Deng J, Wang X, Luo Y, Li J, Zhao Y, Zhang H*. Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia. Cell Death Differ 2022 Jan 21. doi: 10.1038/s41418-022-00938-9.
  3. H Zhang#, XX Wu#, XM Li, M Li, F Li, LX Wang, XX Zhang, Y Zhang, Y Luo, H Zhang*. Crucial role of the Receptor-interacting protein homotypic interaction motifs (RHIM) of RIPK3 in RIPK1 dependent cell death and lymphoproliferative disease. Cell Reports 2020 May 19;31(7):107650.
  4. Zhang Y, Li M, Li X, Zhang H, Wang L, Wu X, Zhang H*, Luo Y*. Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation. Cell Death and Disease 2020 Jul 23;11(7):565.
  5. XX Zhang#, HW Zhang#, CX Xu, XM Li, M Li, XX Wu, WJ Pu, B Zhou, HK Wang, DL Li, QR Ding, H Ying, H Wang, H Zhang*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Communication 2019 Sep 13;10(1):4158.
  6. Zhao Q#, Yu X#, Li M, Liu Y, Han Y, Zhang X, Li XM, Wu X, Qin J, Fang J, Zhang H*. MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses. Cancer Letter 2019 Sep 10;459:100-111.
  7. C Xu, X Wu, X Zhang, Q Xie, C Fan, H Zhang*. Embryonic lethality and host immunity of RelA-deficient mice is mediated by both apoptosis and necroptosis. Journal of Immunology 2018 Jan 1;200(1):271-285.
  8. Zhang X, Zhang H*. Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME. Sci China Life Sci 2018 Jun;61(6):739-740.
  9. Zhao Q, Yu X, Zhang H, Liu Y, Zhang X, Wu X, Xie Q, Li M, Ying H, H Zhang*. RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell Reports 2017 Apr 25;19(4):798-808.
  10. Y Liu#, C Fan#, Y Zhang, X Yu, X Wu, X Zhang, Q Zhao, H Zhang, Q Xie, M Li, X Li, Q Ding, H Ying, D Li, H Zhang*. RIP1 Kinase Activity dependent roles in embryonic development of Fadd-deficient mice. Cell Death and Differentiation 2017 Aug;24(8):1459-1469.
  11. X Yu#,*, Q Zhao#, X Zhang, H Zhang, Y Liu, X Wu, M Li, X Li , J Zhang, X Ruan, H Zhang*. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation. Oncotarget 2017 Jun 27;8(40):67300-67314.
  12. X Zhang#, C Fan#, HW Zhang, Q Zhao, Y Liu, C Xu, Q Xie, X Wu, X Yu, J Zhang, H Zhang*. MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome. Cell Reports 2016 Sep 20;16(12):3247-3259.
  13. C Fan#, W Pu#, X Wu, X Zhang, L He, B Zhou*, H Zhang*. Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death and Disease 2016 Sep 1;7(9):e2351.
  14. Yu X, Zhao Q, Zhang H, Fan C, Zhang X, Xie Q, Xu C, Liu Y, Wu X, Han Q*, H Zhang*. Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages. Acta Biochim Biophys Sin 2016 May;48(5):454-461.
  15. Zhang HW, Zhang X, Fan C, Xie Q, Xu C, Qun Zhao, Liu Y, Wu X, H Zhang*. A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells. Biochem Biophys Res Commun 2016 Mar 18;471(4):528-532.
  16. Zhang H, Zhou X, McQuade T, Li J, Chan FK*, Zhang J*. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 2011 Mar 17;471(7338):373-376.
  17. Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J*. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol 2009 Jan 1; 182(1):207-15.
  18. Zhang H#, Hou YJ#, Han SY, Zhang EC, Huebner K, Zhang J*. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Int Immunol 2009 Jun; 21(6):691-703.