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全体研究组长

谢东

中科院营养代谢与食品安全重点实验室，肿瘤分子生物学课题组组长

研究方向：肿瘤发生和转移过程中的分子机制研究

电子邮件(E-mail)：dxie@sibs.ac.cn

电话(Tel)：021-54920918

传真(Fax)：021-54920291

简历
2017-至　 今：中国科学院上海营养与健康研究所 研究员
2011-2016年：中国科学院上海生命科学研究院营养科学研究所 党委书记、副所长
2004-2016年：中国科学院上海生命科学研究院营养科学研究所 研究员
2000-2004年：美国加州大学洛杉矶分校（UCLA）医学院 助理教授
1997-2000年：美国加州大学洛杉矶分校西赛医学中心 博士后
1992-1997年：美国南卡罗来纳大学 分子生物系 博士
1989-1992年：东华理工大学 讲师
1986-1989年：中国科学院遗传所 硕士
1983-1986年：东华理工大学 助教
1979-1983年：江西大学（现南昌大学）生物系 学士

研究内容
1. 利用细胞及动物模型并结合临床样本，研究酪氨酸受体激酶Eph/ephrin家族成员在肿瘤发生发展中的双重调控作用机理和信号转导。
2. 接头蛋白RACK1生物学功能研究，包括RACK1对Wnt、Hedgehog等信号通路的影响，及RACK1在炎症、干扰素相关肿瘤免疫中的作用及信号转导。
3. 针对Ephs/ephrins及相关分子的药物靶标筛选，探寻肿瘤起始细胞（Tumor Initiating Cells, TICs）与药物抗性之间的联系，开发新的治疗肿瘤的药物。

代表性论文（* 通讯作者）

  1. Ma N, Wang YK, Xu S, Ni QZ, Zheng QW, Zhu B, Cao HJ, Jiang H, Zhang FK, Yuan YM , Zhang EB, Chen TW, Xia J, Ding XF, Chen ZH, Zhang XP, Wang K, Cheng SQ, Qiu L, Li ZG, Yu YC, Wang XF, Zhou B, Li JJ, Xie D*. (2021) PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Nat Commun 12:3059
  2. Jiang H, Cao HJ, Ma N, Bao WD, Wang JJ, Chen TW, Zhang EB, Yuan YM, Ni QZ, Zhang FK, Ding XF, Zheng QW, Wang YK, Zhu M, Wang X, Feng J, Zhang XL, Cheng SQ, Ma DJ, Qiu L, Li JJ, Xie D*.（2020）Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis. Proc Natl Acad Sci U S A Mar 3;117(9):4770-4780
  3. Chen TW, Yin FF, Yuan YM, Guan DX, Zhang E, Zhang FK, Jiang H, Ma N, Wang JJ, Ni QZ, Qiu L, Feng J, Zhang XL, Bao Y, Wang K, Cheng SQ, Wang XF, Wang X, Li JJ, Xie D*. (2019) Liver Cancer: CHML promotes metastasis by facilitating Rab14 recycle. Nat Commun Jun 7;10(1):2510
  4. Yuan YM, Ma N, Zhang EB, Chen TW, Jiang H, Yin FF, Wang JJ, Zhang FK, Ni QZ, Wang X, Bao Y, Wang K, Cheng SQ, Zhang XL, Wang XF, Li JJ, Xie D*. (2019) BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. Oncogene Nov;38(48):7281-7293
  5. Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, Qian ZY, Zhang EB, Feng D, Zhou QL, Du YN, Liu DP, Huang XX, Liu LM, Chin E, Li DS, Wang XF, Zhang XL, Xie D*. (2018) Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. J Exp Med Jan 2;215(1):177-195
  6. Cai Z, Qian ZY, Jiang H, Ma N, Li Z, Liu LY, Ren XX, Shang YR, Wang JJ, Li JJ, Liu DP, Zhang XP, Feng D, Ni QZ, Feng YY, Li N, Zhou XY, Wang X, Bao Y, Zhang XL, Deng YZ, Xie D*. (2018) hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling. Cancer Res 15;78(10):2536-2549
  7. Zhou W, Ye XL, Xu J, Cao MG, Fang ZY, Li LY, Guan GH, Liu Q, Qian YH, Xie D*. (2017) The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Science signaling Jun 13;10(483):eaak9557
  8. Li JJ, Sun ZJ, Yuan YM, Yin FF, Bian YG, Long LY, Zhang XL, Xie D*. (2017) EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 292(3):1112-1121
  9. Bao WD, Fan Y, Deng YZ, Long LY, Wang JJ, Guan DX, Qian ZY, Feng YY, He ZY, Wang XF, Phillip Koeffler H, Hu R, Wang J, Wang X, Wang F, Li JJ, Xie D*. (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. J Hepatol 65(1):137-145
  10. Guan DX, Shi J, Zhang Y, Zhao JS, Long LY, Chen TW, Zhang EB, Feng YY, Bao WD, Deng YZ, Qiu L, Zhang XL, Koeffler HP, Cheng SQ, Li JJ, Xie D*. (2015) Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 62(6):1791-1803
  11. Li, JJ, Xie D*. (2015) RACK1, a versatile hub in cancer. Oncogene Apr 9;34(15):1890-1898
  12. Long L, Deng Y, Yao F, Guan D, Feng Y, Jiang H, Li X, Hu P, Lu X, Wang H, Li J, Gao X, Xie D*. (2014) Recruitment of Phosphatase PP2A by RACK1 Adaptor Protein Deactivates Transcription Factor IRF3 and Limits Type I Interferon Signaling. Immunity Apr 17;40(4):515-529
  13. Yao F, Long LY, Deng YZ, Feng YY, Ying GY, Bao WD, Li G, Guan DX, Zhu YQ, Li JJ, Xie D*. (2014) RACK1 Modulates NF-κB Activation by Interfering with the Interaction between TRAF2 and the IKK Complex. Cell Research 24(3):359-371
  14. Zhang Y, Guan DX, Shi J, Gao H, Li JJ, Zhao JS, Qiu L, Liu J, Li N, Guo WX, Xue J, Zhou FG, Wu MC, Wang HY, Xie D*, Cheng SQ*. (2013) All-trans retinoic acid potentiates the chemotherapeutic effect of Cisplatin by inducing differentiation of tumor initiating cells in liver cancer. J Hepatol Dec;59(6):1255-1263
  15. Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, Deng Y, Zhao J, Jiang S, Yuan Y, Wang HY, Cheng SQ, Xie D*, Wang XF*. (2012) TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 22(3):291-303
  16. Li G, Ji XD, Gao H, Zhao JS, Xu JF, Sun ZJ, Deng YZ, Shi S, Feng YX, Zhu YQ, Wang T, Li JJ, Xie D*. (2012) EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Aktsignalling complex. Nat Commun Feb 7;3:667
  17. Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, Li G, Ji XD, Shi S, Guan DX, Feng YY, Cui L, Li DS, Liu Y, Du X, Guo MZ, Xu LY, Li EM, Wang HY, Xie D*. (2012) RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology 142(4):812-823.e815
  18. Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, Li G, Li JJ, Zhu D, Koeffler HP, Zhao Y, Xie D*. (2012) RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem 287(11):7845-7858
  19. Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, Yao F, Zhu YQ, Qin Y, Wang H, Li N, Wu MC, Wang HY, Wang XF, Cheng SQ, Xie D*. (2011) Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model. Hepatology 53(2):483-492
  20. Ji XD, Li G, Feng YX, Zhao JS, Li JJ, Sun ZJ, Shi S, Deng YZ, Xu JF, Zhu YQ, Koeffler HP, Tong XJ, Xie D*. (2011) EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Res 71(3):1156-1166
  21. Feng YX, Zhao JS, Li JJ, Wang T, Cheng SQ, Yuan Y, Wang F, Wang XF, Xie D*. (2010) Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology 51(2):535-544
  22. Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, Qiu YP, Chen PP, Li WJ, Xu LY, Li EM, Tam JP, Qi RZ, Jia W*, Xie D*. (2010) A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics 9(12):2617-2628