其他博士生导师

张国庆
博士 研究员 博士生导师

中国遗传学会生物大数据专业委员会委员、中国医药生物技术协会生物医学信息技术分会委员。
中科院上海生命科学研究院生物医学大数据中心平台课题组长、中心副主任

研究方向:生物医学大数据

电子邮件(E-mail):gqzhang@picb.ac.cn

电话(Tel):13524783378

传真(Fax):021-54920451

简历
2017-至     今:中国科学院上海营养与健康研究所 生物医学大数据中心副主任,平台课题组长
2016-2017年:中国科学院上海生命科学研究院 生物医学大数据中心副主任,平台课题组长
2007-2016年:上海生物信息技术研究中心 生命科学数据中心部门主管
2006-2007年:上海生物信息技术研究中心 生命科学数据中心技术骨干
2003-2006年:华中科技大学生命科学与技术学院 生物医学工程专业 博士
2000-2003年:华中科技大学生命科学与技术学院 生物医学工程专业 硕士

研究内容
1. 生物医学大数据综合平台
2. 生命科学知识库
3. 精准医学知识库

代表性论文 (* 通讯作者)

  1. Meng Hao, Weilin Pu, Yi Li, Shaoqing Wen, Chang Sun, Yanyun Ma, Hongxiang Zheng, Xingdong Chen, Jingze Tan, Guoqing Zhang, Menghan Zhang, Shuhua Xu, Yi Wang, Hui Li, Jiucun Wang, Li Jin. The HuaBiao project: whole-exome sequencing of 5000 Han Chinese individuals. J Genet Genomics 2021 Nov 20;48(11):1032-1035
  2. Zhang Lu, Cao Ruifang, Mao Tiantian, Wang Yuan, Lv Daqing, Yang Liangfu, Tang Yuanyuan, Zhou Mengdi, Ling Yunchao, Zhang Guoqing#, Qiu Tianyi#, Cao Zhiwei#. SAS: A Platform of Spike Antigenicity for SARS-CoV-2. Front Cell Dev Biol 2021 Sep 20;9:713188.
  3. CNCB-NGDC Members and Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res 2021 Jan 8;49(D1):D18-D28.
  4. Wendi Huang, Yunchao Ling, Sirui Zhang, Qiguang Xia, Ruifang Cao, Xiaojuan Fan, Zhaoyuan Fang, Zefeng Wang#, Guoqing Zhang#. TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence. Nucleic Acids Res 2021 Jan 8;49(D1):D236-D242.
  5. Hangyu Zhang, Liyun Yuan, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang, Yi Zheng, Peng Zhao, Guoqing Zhang#, Weijia Fang#. Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab. BMC Cancer 2020 May 13;20(1):416.
  6. Ying Wang, Ning Li, Jun-Jie Yang, Dong-Mei Zhao, Bin Chen, Guo-Qing Zhang, Shuo Chen, Rui-Fang Cao, Han Yu, Chang-Ying Zhao, Lu Zhao, Yong-Sheng Ge, Yi Liu, Le-Hai Zhang, Wei Hu, Lei Zhang, Zhong-Tao Gai. Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacol Res 2020 Jul;157:104784.
  7. Dingfeng Wu, Wenxing Gao, Xiaoyi Li, Chuan Tian, Na Jiao, Sa Fang, Jing Xiao, Zhifeng Xu, Lixin Zhu#, Guoqing Zhang#, Ruixin Zhu#. Dr AFC: drug repositioning through anti-fibrosis characteristic. Brief Bioinform 2021 May 20;22(3):bbaa115.
  8. Chenfen Zhou, Qingwei Xu, Sheng He, Wei Ye, Ruifang Cao, Pengyu Wang, Yunchao Ling, Xing Yan, Qingzhong Wang, Guoqing Zhang#. GTDB: an integrated resource for glycosyltransferase sequences and annotations. Database (Oxford) 2020 Jan 1;2020:baaa047.
  9. Shijie C Zheng, Charles E Breeze, Stephan Beck, Danyue Dong, Tianyu Zhu, Liangxiao Ma, Wei Ye, Guoqing Zhang, Andrew E Teschendorff#. EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI. Bioinformatics 2019 Nov 9;36(6):1950-1951.
  10. National Genomics Data Center Members and Partners. Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res 2020 Jan 8;48(D1):D24-D33.
  11. Hong Sun#, Yangfan Guo, Xiaoping Lan, Jia Jia, Xiaoshu Cai, Guoqing Zhang, Jingjing Xie, Qian Liang, Yixue Li, Guangjun Yu#. PhenoModifier: a genetic modifier database for elucidating the genetic basis of human phenotypic variation. Nucleic Acids Res 2020 Jan 8;48(D1):D977-D982.
  12. Yang Gao, Chao Zhang, Liyun Yuan, YunChao Ling, Xiaoji Wang, Chang Liu, Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu, Kai Yuan, Wei Ye, Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju, Long Dai, Yuanyuan Tang, The Han100K Initiative, Guoqing Zhang, Shuhua Xu#. PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Res 2020 Jan 8;48(D1):D971-D976.
  13. Dalang Yu, Lili Dong, Fangqi Yan, Hailong Mu, Bixia Tang, Xiao Yang, Tao Zeng, Qing Zhou, Feng Gao, Zhonghuang Wang, Ziqian Hao, Hongen Kang, Yi Zheng, Hongwei Huang, Yuzhang Wei, Wei Pan, Yaochen Xu, Junwei Zhu, Shilei Zhao, Ciran Wang, Pengyu Wang, Long Dai, Mushan Li, Li Lan, Yiwei Wang, Hua Chen, Yixue Li, Yunxin Fu, Zhen Shao, Yiming Bao, Fangqing Zhao, Luonan Chen, Guoqing Zhang#, Wenming Zhao#, Haipeng Li#. eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses. Natl Sci Rev 2019 Oct;6(5):867-869.
  14. Jie Ma, Tao Chen, Songfeng Wu, Chunyuan Yang, Mingze Bai, Kunxian Shu, Kenli Li, Guoqing Zhang, Zhong Jin, Fuchu He, Henning Hermjakob, Yunping Zhu. iProX: an integrated proteome resource. Nucleic Acids Res 2019 Jan 8;47(D1):D1211-D1217.
  15. Shuang Yang, Guoqing Zhang, Wan Liu, Zhen Wang, Jifeng Zhang, Dongshan Yang, Y. Eugene Chen, Hong Sun, Yixue Li. SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity. J Genet Genomics 2017 May 20;44(5):251-258.
  16. Zhi-Tao Yang, Su-Yuan Huang, Li Chen, Feng Liu, Xiao-Hui Cai, Yang-Fan Guo, Ming-Jie Wang, Yue Han, De-Min Yu, Jie-Hong Jiang, Dong-Hua Zhang, Qi-Ming Gong, Guo-Qing Zhang, Zhong-Hua Lu, Li-Hua Huang, Xin-Xin Zhang. Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection. J Clin Microbiol 2015 Jul;53(7):2203-2214.
  17. Guoqing Zhang, Yunsheng Zhang, Yunchao Ling, Jia Jia. Web Resources for Pharmacogenomics. Genomics, Proteomics & Bioinformatics 2015 Feb;13(1):51-54.
  18. Jing Li, Jia Jia, Hong Li, Jian Yu, Han Sun, Ying He, Daqing Lv, Xiaojuan Yang, Michael O. Glocker, Liangxiao Ma, Jiabei Yang, Ling Li, Wei Li, Guoqing Zhang, Qian Liu, Yixue Li, Lu Xie. SysPTM 2.0: an updated systematic resource for post-translational modification. Database (Oxford) 2014 Apr 3;2014:bau025.
  19. Jian Chen, Jia Sheng, Dijing Lv, Yang Zhong, Guoqing Zhang#, Peng Nan#. The optimization of running time for a maximum common substructure-based algorithm and its application in drug design. Comput Biol Chem 2014 Feb;48:14-20.
  20. Shen Niu, Zhen Wang, Dongya Ge, Guoqing Zhang, Yixue Li. Prediction of functional phosphorylation sites by incorporating evolutionary information. Protein Cell 2012 Sep;3(9):675-690.
  21. Jian Yu, Xiaobin Xing, Lingyao Zeng, Jiehuan Sun, Wei Li, Han Sun, Ying He, Jing Li, Guoqing Zhang, Chuan Wang, Yixue Li, Lu Xie. SyStemCell: A Database Populated with Multiple Levels of Experimental Data from Stem Cell Differentiation Research. PLoS One 2012;7(7):e35230.
  22. Ying He, Menghuan Zhang, Yuanhu Ju, Zhonghao Yu, Daqing Lv, Han Sun, Weilan Yuan, Fei He, Jianshe Zhang, Hong Li, Jing Li, Rui Wang-Sattler, Yixue Li, Guoqing Zhang#, Lu Xie#. dbDEPC 2.0: updated database of differentially expressed proteins in human cancers. Nucleic Acids Res 2012 Jan;40(Database issue):D964-D971.
  23. Tao Huang, Chuan Wang, Guoqing Zhang, Lu Xie, Yixue Li. SySAP: a system-level predictor of deleterious single amino acid polymorphisms. Protein Cell 2012 Jan;3(1):38-43.
  24. Hui Dong, Yanjun Zhang, Hui Xiong, An Yan, Guohui Ding, Yangyi Chen, Liqun Xie, Jiazheng Chen, Guoqing Zhang, Pei Hao, Liming Cong, Yiyu Lu, Xiaoyan Che, Xiaoning Wang, Yixue Li, Kwok-Yung Yuen, Guoping Zhao, Weirong Jin. Detection of human novel influenza A (H1N1) viruses using multi-fluorescent real-time RT-PCR. Virus Res 2010 Jan;147(1):85-90.
  25. Hui Yu, Fudong Yu, Guoqing Zhang, Xiang Shen, Yunqin Chen, Yuanyuan Li, Yixue Li. DBH2H: vertebrate head-to-head gene pairs annotated at genomic and post-genomic levels. Database (Oxford) 2009;2009:bap006.
  26. Qingwei Xu, Yixiang Shi, Qiang Lu, Guoqing Zhang, Qingming Luo, Yixue Li. GORouter: an RDF model for providing semantic query and inference services for Gene Ontology and its associations. BMC Bioinformatics 2008;9 Suppl 1(Suppl 1):S6.
  27. Hao Pei, Chen Min, Zhang Guoqing, He Weizhong, Li Yixue. Bioinformatics Research on the SARS Coronavirus (SARS_CoV) in China. Curr Pharm Des 2006;12(35):4565-4572.
  28. Fang Zhou, Luo Qingming, Zhang Guoqing, Li Yixue. Biological networks to the analysis of microarray data. Progress in Natural Science 2006;16(12):1242-1251.
  29. Guo-qing Zhang, Zhi-wei Cao, Qing-ming Luo, Yu-dong Cai, Yi-xue Li. Operon prediction based on SVM. Computational Biology and Chemistry 2006;30(3):233-240.